[PDF][PDF] SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells
…, M Popa, R Hovland, Ø Bruserud, BT Gjertsen, YH Kuo… - Cell stem cell, 2014 - cell.com
The FLT3-ITD mutation is frequently observed in acute myeloid leukemia (AML) and is
associated with poor prognosis. In such patients, FLT3 tyrosine kinase inhibitors (TKIs) are only …
associated with poor prognosis. In such patients, FLT3 tyrosine kinase inhibitors (TKIs) are only …
[HTML][HTML] Cbfβ-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia
YH Kuo, SF Landrette, SA Heilman, PN Perrat… - Cancer cell, 2006 - cell.com
The acute myeloid leukemia (AML)-associated CBFβ-SMMHC fusion protein impairs
hematopoietic differentiation and predisposes to leukemic transformation. The mechanism of …
hematopoietic differentiation and predisposes to leukemic transformation. The mechanism of …
[HTML][HTML] Acquired miR-142 deficit in leukemic stem cells suffices to drive chronic myeloid leukemia into blast crisis
…, L Li, J Jin, J Chen, J Yu, MA Caligiuri, YH Kuo… - Nature …, 2023 - nature.com
The mechanisms underlying the transformation of chronic myeloid leukemia (CML) from
chronic phase (CP) to blast crisis (BC) are not fully elucidated. Here, we show lower levels of …
chronic phase (CP) to blast crisis (BC) are not fully elucidated. Here, we show lower levels of …
Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia
Leukemia stem cells (LSCs) in individuals with chronic myelogenous leukemia (CML) (hereafter
referred to as CML LSCs) are responsible for initiating and maintaining clonal …
referred to as CML LSCs) are responsible for initiating and maintaining clonal …
Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11
SF Landrette, YH Kuo, K Hensen… - Blood, 2005 - ashpublications.org
Recurrent chromosomal rearrangements are associated with the development of acute
myeloid leukemia (AML). The frequent inversion of chromosome 16 creates the CBFB-MYH11 …
myeloid leukemia (AML). The frequent inversion of chromosome 16 creates the CBFB-MYH11 …
[PDF][PDF] HDAC8 inhibition specifically targets Inv (16) acute myeloid leukemic stem cells by restoring p53 acetylation
…, G Marcucci, R Bhatia, WJ Huang, CI Chang, YH Kuo - Cell stem cell, 2015 - cell.com
Acute myeloid leukemia (AML) is driven and sustained by leukemia stem cells (LSCs) with
unlimited self-renewal capacity and resistance to chemotherapy. Mutation in the TP53 tumor …
unlimited self-renewal capacity and resistance to chemotherapy. Mutation in the TP53 tumor …
The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents
…, H Liu, A Lin, SJ Forman, YH Kuo… - Blood, The Journal …, 2013 - ashpublications.org
The SRC family kinases (SFKs) and the receptor tyrosine kinase c-Kit are activated in human
acute myeloid leukemia (AML) cells. We show here that the SFKs LYN, HCK, or FGR are …
acute myeloid leukemia (AML) cells. We show here that the SFKs LYN, HCK, or FGR are …
Leukemia cell–targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity
Signal transducer and activator of transcription 3 (STAT3) is an oncogene and immune
checkpoint commonly activated in cancer cells and in tumor-associated immune cells. We …
checkpoint commonly activated in cancer cells and in tumor-associated immune cells. We …
Runx2 induces acute myeloid leukemia in cooperation with Cbfβ-SMMHC in mice
YH Kuo, SK Zaidi, S Gornostaeva… - Blood, The Journal …, 2009 - ashpublications.org
The core-binding factor (CBF) is a master regulator of developmental and differentiation
programs, and CBF alterations are frequently associated with acute leukemia. The role of the …
programs, and CBF alterations are frequently associated with acute leukemia. The role of the …
Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia
…, B Zhang, Q Cai, P Swiderski, YH Kuo… - Blood, The Journal …, 2016 - ashpublications.org
Targeting oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3)
in acute myeloid leukemia (AML) can reduce blast survival and tumor immune evasion…
in acute myeloid leukemia (AML) can reduce blast survival and tumor immune evasion…