DNA double‐strand breaks (DSBs) are dangerous lesions that can lead to genomic instability
and cell death. Eukaryotic cells repair DSBs either by nonhomologous end‐joining (NHEJ) …

Damage to the mitotic spindle and centrosome dysfunction can lead to cancer. To prevent
this, cells trigger a succession of checkpoint responses, where an initial mitotic delay is …

The p53 tumor suppressor protein acts as a major defense against cancer. Among its most
distinctive features is the ability to elicit both apoptotic death and cell cycle arrest. In this issue …

Histone monoubiquitylation is implicated in critical regulatory processes. We explored the
roles of histone H2B ubiquitylation in human cells by reducing the expression of hBRE1/…

Aneuploidy, often preceded by tetraploidy, is one of the hallmarks of solid tumors. Indeed,
both aneuploidy and tetraploidy are oncogenic occurrences that are sufficient to drive …

Proper cellular functionality and homeostasis are maintained by the convergent integration of
various signaling cascades, which enable cells to respond to internal and external changes…

Apoptosis is an important mechanism to eliminate potentially tumorigenic cells. The tumor
suppressor p53 plays a pivotal role in this process. Many tumors harbor mutant p53, but others …

Genome stability is of primary importance for the survival and proper functioning of all organisms.
Double-strand breaks (DSBs) arise spontaneously during growth, or can be created by …

Post‐translational histone modifications have essential roles in controlling nuclear processes;
however, the specific mechanisms regulating these modifications and their combinatorial …

The p53 tumor suppressor and its paralogs p63 and p73 are at the crux of a network
modulating cellular responses against potentially tumorigenic events. p53 acts primarily as a …