Linker histone H1 proteins bind to nucleosomes and facilitate chromatin compaction 1 , although
their biological functions are poorly understood. Mutations in the genes that encode H1 …

H1 linker histones are the most abundant chromatin-binding proteins 1 . In vitro studies
indicate that their association with chromatin determines nucleosome spacing and enables …

Epigenetic modifications, including those on DNA and histones, have been shown to regulate
cellular metabolism by controlling expression of enzymes involved in the corresponding …

The ubiquitin-proteasome pathway plays a crucial role in many cellular processes by degrading
substrates tagged by polyubiquitin chains, linked mostly through lysine 48 of ubiquitin. …

Elucidating the molecular details of how chromatin-associated factors deposit, remove and
recognize histone post-translational modification (PTM) signatures remains a daunting task in …

Cellular proteins continuously undergo non-enzymatic covalent modifications (NECMs) that
accumulate under normal physiological conditions and are stimulated by changes in the …

Post-translational modification of the histone proteins in chromatin plays a central role in the
epigenetic control of DNA-templated processes in eukaryotic cells. Developing methods that …

Chromosomal instability (CIN) and epigenetic alterations are characteristics of advanced
and metastatic cancers 1 , 2 , 3 – 4 , but whether they are mechanistically linked is unknown. …

The ability to manipulate the chemical composition of proteins and peptides has been
central to the development of improved polypeptide-based therapeutics and has enabled …

DOT1L, the only H3K79 methyltransferase in human cells and a homolog of the yeast Dot1,
normally forms a complex with AF10, AF17, and ENL or AF9, is dysregulated in most cases …