[HTML][HTML] FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices

…, S Myong, D Nettels, TO Peulen, E Ploetz, Y Razvag… - Elife, 2021 - elifesciences.org
Single-molecule FRET (smFRET) has become a mainstream technique for studying biomolecular
structural dynamics. The rapid and wide adoption of smFRET experiments by an ever-…

[HTML][HTML] Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation

Y Razvag, Y Neve-Oz, J Sajman, M Reches… - Nature …, 2018 - nature.com
T cells have a central function in mounting immune responses. However, mechanisms of
their early activation by cognate antigens remain incompletely understood. Here we use live-…

Coassembly of aromatic dipeptides into biomolecular necklaces

S Yuran, Y Razvag, M Reches - Acs Nano, 2012 - ACS Publications
This paper describes the formation of complex peptide-based structures by the coassembly
of two simple peptides, the diphenylalanine peptide and its tert-butyl dicarbonate (Boc) …

Probing the interaction of individual amino acids with inorganic surfaces using atomic force spectroscopy

Y Razvag, V Gutkin, M Reches - Langmuir, 2013 - ACS Publications
This article describes single-molecule force spectroscopy measurements of the interaction
between individual amino acid residues and inorganic surfaces in an aqueous solution. In …

[PDF][PDF] T cell activation through isolated tight contacts

Y Razvag, Y Neve-Oz, J Sajman, O Yakovian… - Cell Reports, 2019 - cell.com
T cells engage antigen-presenting cells in search for cognate antigens via dynamic cell
protrusions before forming a tight immune synapse. The spatiotemporal events that may lead to …

Elucidating the mechanism of interaction between peptides and inorganic surfaces

S Maity, D Zanuy, Y Razvag, P Das… - Physical Chemistry …, 2015 - pubs.rsc.org
Understanding the mechanism of interaction between peptides and inorganic materials is of
high importance for the development of new composite materials. Here, we combined an …

[HTML][HTML] Mechanisms of localized activation of the T cell antigen receptor inside clusters

Y Neve-Oz, Y Razvag, J Sajman, E Sherman - Biochimica et Biophysica …, 2015 - Elsevier
The T cell antigen receptor (TCR) has been shown to cluster both before and upon engagement
with cognate antigens. However, the effect of TCR clustering on its activation remains …

ForSDAT: An automated platform for analyzing force spectroscopy measurements

T Duanis-Assaf, Y Razvag, M Reches - Analytical methods, 2019 - pubs.rsc.org
Single molecule force spectroscopy using an atomic force microscope is a common method
in the study of ligand–receptor interactions, adhesion events and protein folding. Such …

Optimization of liganded polyethylenimine polyethylene glycol vector for nucleic acid delivery

…, A Shir, N Edinger, A Sagalov, Y Razvag… - Bioconjugate …, 2014 - ACS Publications
The delivery of nucleic acids into cells is an attractive approach for cancer therapy.
Polyethylenimine (PEI) is among the most efficient nonviral carriers. Recent studies have …

[HTML][HTML] Gp41 dynamically interacts with the TCR in the immune synapse and promotes early T cell activation

…, R Schwarzer, J Sajman, Y Neve-Oz, Y Razvag… - Scientific reports, 2018 - nature.com
The HIV-1 glycoprotein gp41 critically mediates CD4 + T-cell infection by HIV-1 during viral
entry, assembly, and release. Although multiple immune-regulatory activities of gp41 have …