[HTML][HTML] FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices
Single-molecule FRET (smFRET) has become a mainstream technique for studying biomolecular
structural dynamics. The rapid and wide adoption of smFRET experiments by an ever-…
structural dynamics. The rapid and wide adoption of smFRET experiments by an ever-…
[HTML][HTML] Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation
T cells have a central function in mounting immune responses. However, mechanisms of
their early activation by cognate antigens remain incompletely understood. Here we use live-…
their early activation by cognate antigens remain incompletely understood. Here we use live-…
Coassembly of aromatic dipeptides into biomolecular necklaces
S Yuran, Y Razvag, M Reches - Acs Nano, 2012 - ACS Publications
This paper describes the formation of complex peptide-based structures by the coassembly
of two simple peptides, the diphenylalanine peptide and its tert-butyl dicarbonate (Boc) …
of two simple peptides, the diphenylalanine peptide and its tert-butyl dicarbonate (Boc) …
Probing the interaction of individual amino acids with inorganic surfaces using atomic force spectroscopy
Y Razvag, V Gutkin, M Reches - Langmuir, 2013 - ACS Publications
This article describes single-molecule force spectroscopy measurements of the interaction
between individual amino acid residues and inorganic surfaces in an aqueous solution. In …
between individual amino acid residues and inorganic surfaces in an aqueous solution. In …
[PDF][PDF] T cell activation through isolated tight contacts
T cells engage antigen-presenting cells in search for cognate antigens via dynamic cell
protrusions before forming a tight immune synapse. The spatiotemporal events that may lead to …
protrusions before forming a tight immune synapse. The spatiotemporal events that may lead to …
Elucidating the mechanism of interaction between peptides and inorganic surfaces
Understanding the mechanism of interaction between peptides and inorganic materials is of
high importance for the development of new composite materials. Here, we combined an …
high importance for the development of new composite materials. Here, we combined an …
[HTML][HTML] Mechanisms of localized activation of the T cell antigen receptor inside clusters
The T cell antigen receptor (TCR) has been shown to cluster both before and upon engagement
with cognate antigens. However, the effect of TCR clustering on its activation remains …
with cognate antigens. However, the effect of TCR clustering on its activation remains …
ForSDAT: An automated platform for analyzing force spectroscopy measurements
T Duanis-Assaf, Y Razvag, M Reches - Analytical methods, 2019 - pubs.rsc.org
Single molecule force spectroscopy using an atomic force microscope is a common method
in the study of ligand–receptor interactions, adhesion events and protein folding. Such …
in the study of ligand–receptor interactions, adhesion events and protein folding. Such …
Optimization of liganded polyethylenimine polyethylene glycol vector for nucleic acid delivery
…, A Shir, N Edinger, A Sagalov, Y Razvag… - Bioconjugate …, 2014 - ACS Publications
The delivery of nucleic acids into cells is an attractive approach for cancer therapy.
Polyethylenimine (PEI) is among the most efficient nonviral carriers. Recent studies have …
Polyethylenimine (PEI) is among the most efficient nonviral carriers. Recent studies have …
[HTML][HTML] Gp41 dynamically interacts with the TCR in the immune synapse and promotes early T cell activation
The HIV-1 glycoprotein gp41 critically mediates CD4 + T-cell infection by HIV-1 during viral
entry, assembly, and release. Although multiple immune-regulatory activities of gp41 have …
entry, assembly, and release. Although multiple immune-regulatory activities of gp41 have …