Background— C-reactive protein (CRP) is a heritable marker of chronic inflammation that is
strongly associated with cardiovascular disease. We sought to identify genetic variants that …

The QRS interval, from the beginning of the Q wave to the end of the S wave on an
electrocardiogram, reflects ventricular depolarization and conduction time and is a risk factor for …

C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is
associated with multiple complex diseases. The genetic determinants of chronic inflammation …

A polymorphism of the human angiotensin-1-converting enzyme (ACE) gene has been identified
in which the presence (insertion, I allele) of a 287-bp fragment rather than the absence (…

Background— Left ventricular hypertrophy (LVH) occurs as an adaptive response to a
physiological (such as exercise) or pathological (valvular disease, hypertension, or obesity) …

PPARα is a nuclear receptor that controls lipid and glucose metabolism and exerts antiinflammatory
activities. The factors regulating human PPARα (hPPARα) gene expression remain …

Background— Peroxisome proliferator-activated receptor α (PPARα) regulates the expression
of genes involved in lipid metabolism and inflammation, making it a candidate gene for …

Background— Drug-induced long-QT syndrome (diLQTS) is an adverse drug effect that has
an important impact on drug use, development, and regulation. We tested the hypothesis …

Background C-reactive protein (CRP) is associated with immune, cardiometabolic, and
psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal. …

Higher resting heart rate is associated with increased cardiovascular disease and mortality
risk. Though heritable factors play a substantial role in population variation, little is known …