User profiles for Yali Dou
 | Yali DouUniversity of Southen California Verified email at usc.edu Cited by 15660 |
[HTML][HTML] Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
A stable complex containing MLL1 and MOF has been immunoaffinity purified from a
human cell line that stably expresses an epitope-tagged WDR5 subunit. Stable interactions …
human cell line that stably expresses an epitope-tagged WDR5 subunit. Stable interactions …
Regulation of MLL1 H3K4 methyltransferase activity by its core components
Histone H3 Lys4 (H3K4) methylation is a prevalent mark associated with transcription
activation. A common feature of several H3K4 methyltransferase complexes is the presence of …
activation. A common feature of several H3K4 methyltransferase complexes is the presence of …
Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy
…, L Vatan, W Szeliga, J Kotarski, R Tarkowski, Y Dou… - Nature, 2015 - nature.com
Epigenetic silencing including histone modifications and DNA methylation is an important
tumorigenic mechanism 1 . However, its role in cancer immunopathology and immunotherapy …
tumorigenic mechanism 1 . However, its role in cancer immunopathology and immunotherapy …
Hijacked in cancer: the KMT2 (MLL) family of methyltransferases
Histone–lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on the histone
H3 tail at important regulatory regions in the genome and thereby impart crucial functions …
H3 tail at important regulatory regions in the genome and thereby impart crucial functions …
Epigenetic regulation of immune cell functions during post-septic immunosuppression
Studies in humans and animal models indicate that profound immunosuppression is one of
the chronic consequences of severe sepsis. This immune dysfunction encompasses …
the chronic consequences of severe sepsis. This immune dysfunction encompasses …
[HTML][HTML] Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia
…, O Abdel-Wahab, H Lei, Y Dou… - The Journal of …, 2020 - Am Soc Clin Investig
The protein-protein interaction between menin and mixed lineage leukemia 1 (MLL1) plays
a critical role in acute leukemias with translocations of the MLL1 gene or with mutations in …
a critical role in acute leukemias with translocations of the MLL1 gene or with mutations in …
[HTML][HTML] Cryo-EM structure of the human MLL1 core complex bound to the nucleosome
Mixed lineage leukemia (MLL) family histone methyltransferases are enzymes that deposit
histone H3 Lys4 (K4) mono-/di-/tri-methylation and regulate gene expression in mammals. …
histone H3 Lys4 (K4) mono-/di-/tri-methylation and regulate gene expression in mammals. …
Human PAD4 regulates histone arginine methylation levels via demethylimination
…, LS Sonbuchner, CH McDonald, RG Cook, Y Dou… - Science, 2004 - science.org
Methylation of arginine (Arg) and lysine residues in histones has been correlated with
epigenetic forms of gene regulation. Although histone methyltransferases are known, enzymes …
epigenetic forms of gene regulation. Although histone methyltransferases are known, enzymes …
[HTML][HTML] WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development
Histone H3 lysine 4 (K4) methylation has been linked to the transcriptional activation in a
variety of eukaryotic species. Here we show that a common component of MLL1, MLL2, and …
variety of eukaryotic species. Here we show that a common component of MLL1, MLL2, and …
Epigenetic regulation of the alternatively activated macrophage phenotype
Alternatively activated (M2) macrophages play critical roles in diverse chronic diseases,
including parasite infections, cancer, and allergic responses. However, little is known about the …
including parasite infections, cancer, and allergic responses. However, little is known about the …