Large-scale cancer genomic studies enable the systematic identification of mutations that
lead to the genesis and progression of tumors, uncovering the underlying molecular …

Balance between pro-tumor and anti-tumor effects may be affected by molecular interactions
within tumor microenvironment. On this basis we searched for molecular partners of …

The isolation and structural elucidation of a structurally new desertomycin, designated as
desertomycin G (1), with strong antibiotic activity against several clinically relevant antibiotic …

Nineteen members of the ADAMTS family of secreted zinc metalloproteinases are present
in the human degradome. A wide range of different functions are being attributed to these …

Components of the extracellular matrix (ECM) are key players in regulating cellular functions
throughout the whole organism. In fact, ECM components not only participate in tissue …

Fibulins not only function as molecular bridges within the cellular microenvironment but also
influence cell behavior. Thus, fibulins may contribute to create a permissive …

… is a recipient of a contract from the IAO, and Yamina Mohamedi is a recipient of a fellowship
from the FICYT (Principado de Asturias). We thank Drs. Gabriel Bretones, Alejandro Piñeiro, …

Fibulin-2 participates in the assembly of extracellular matrix components through
interactions with multiple ligands and promotes contacts between cells and their surrounding …

The maintenance of tissue homeostasis in any organism is a very complex and delicate process
in which numerous factors intervene. Cellular homeostasis not only depends on intrinsic …

The hyalectan family is composed of the proteoglycans aggrecan, versican, brevican and
neurocan. Hyalectans, also known as lecticans, are components of the extracellular matrix of …