An adaptive variant of the human Ectodysplasin receptor, EDARV370A, is one of the
strongest candidates of recent positive selection from genome-wide scans. We have modeled …

Cell motility is regulated by extracellular cues and by intracellular factors that accumulate at
sites of contact between cells and the extracellular matrix. One of these factors, focal …

Humans sweat to cool their bodies and have by far the highest eccrine sweat gland density
among primates. Humans’ high eccrine gland density has long been recognized as a …

Among the unique features of humans, one of the most salient is the ability to effectively cool
the body during extreme prolonged activity through the evapotranspiration of water on the …

β-Catenin plays an important role in signal transduction pathways that regulate cellular
differentiation and proliferation. The increased concentration of this protein in the cytoplasm …

… Author links open overlay panel Yana G. … Raw quantification and imaging data for
samples used in this study are available upon request from Yana G. Kamberov and Daniel E. …

Eccrine sweat glands are indispensable for human thermoregulation and, similar to other
mammalian skin appendages, form from multipotent epidermal progenitors. Limited …

Enhancers are context-specific regulators of expression that drive biological complexity and
variation through the redeployment of conserved genes. An example of this is the enhancer-…

The Ectodysplasin A2 receptor (XEDAR), is a member of the tumor necrosis factor receptor
subfamily and is a mediator of the Ectodysplasin (EDA) pathway. EDA signaling plays …

… , the medial volar hind-limb in which hair and eccrine glands are interspersed (Kamberov et
… appendage composition are more mild that those of En1 loss (Kamberov et al. 2015; Loomis …