DNA lesions pose a major obstacle during gene transcription by RNA polymerase II (RNAPII)
enzymes. The transcription-coupled DNA repair (TCR) pathway eliminates such DNA …

The response to DNA damage-stalled RNA polymerase II (RNAPIIo) involves the assembly
of the transcription-coupled repair (TCR) complex on actively transcribed strands. The …

Cells employ transcription-coupled repair (TCR) to eliminate transcription-blocking DNA
lesions. DNA damage-induced binding of the TCR-specific repair factor CSB to RNA …

Bulky DNA lesions in transcribed strands block RNA polymerase II (RNAPII) elongation and
induce a genome-wide transcriptional arrest. The transcription-coupled repair (TCR) …

Background Clinical trials to test safety and efficacy of drugs for patients with spinal
muscular atrophy (SMA) are currently underway. Biomarkers that document treatment-induced …

During transcription-coupled DNA repair (TCR), RNA polymerase II (Pol II) transitions from a
transcriptionally active state to an arrested state that allows for removal of DNA lesions. This …

Transcription-blocking DNA lesions are removed by transcription-coupled nucleotide
excision repair (TC-NER) to preserve cell viability. TC-NER is triggered by the stalling of RNA …

Cockayne Syndrome (CS) is a severe neurodegenerative and premature aging autosomal-recessive
disease, caused by inherited defects in the CSA and CSB genes, leading to defects …

Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by brain-specific
loss of UBE3A, an E3 ubiquitin protein ligase. A substantial number of possible …

The response to DNA damage-stalled RNA polymerase II (RNAPIIo) involves the assembly
of the transcription-coupled repair (TCR) complex on actively transcribed strands. The …