Eukaryotic cells make many types of primary and processed RNAs that are found either in
specific subcellular compartments or throughout the cells. A complete catalogue of these …

Data from the Encyclopedia of DNA Elements (ENCODE) project show over 9640 human
genome loci classified as long noncoding RNAs (lncRNAs), yet only ∼100 have been deeply …

The hepatitis B virus (HBV) regulatory protein X (HBx) activates gene expression from the
HBV covalently closed circular DNA (cccDNA) genome. Interaction of HBx with the DDB1-…

The mitochondrial protein MAVS (also known as IPS-1, VISA, and CARDIF) interacts with
RIG-I-like receptors (RLRs) to induce type I interferon (IFN-I). NLRX1 is a mitochondrial …

The success of shotgun proteomic analysis depends largely on how samples are prepared.
Current approaches (such as those that are gel-, solution-, or filter-based), although being …

Nanostructured devices and nanoparticles have fundamentally reshaped the development
of precision healthcare in recent decades. Meanwhile, mass spectrometry (MS)-based …

The second near-infrared (NIR-II) window is a fundamental modality for deep-tissue in vivo
imaging. However, it is challenging to synthesize NIR-II probes with high quantum yields (QYs…

To improve the efficiency, accuracy, reproducibility, throughput and proteome coverage of
mass spectrometry-based quantitative approaches, both in vitro and in vivo tagging of …

Urine culture and microscopy techniques are used to profile the bacterial species present in
urinary tract infections. To gain insight into the urinary flora, we analyzed clinical laboratory …

Over 100 mutations in Cu/Zn-superoxide dismutase (SOD1) result in familial amyotrophic
lateral sclerosis. Dimer dissociation is the first step in SOD1 aggregation, and studies suggest …