The icosahedron is the largest of the Platonic solids, and icosahedral protein structures are
widely used in biological systems for packaging and transport 1 , 2 . There has been …

Transmembrane channels and pores have key roles in fundamental biological processes 1
and in biotechnological applications such as DNA nanopore sequencing 2 , 3 – 4 , resulting …

Complex biological processes are often performed by self-organizing nanostructures
comprising multiple classes of macromolecules, such as ribosomes (proteins and RNA) or …

Protein crystallization plays a central role in structural biology. Despite this, the process of
crystallization remains poorly understood and highly empirical, with crystal contacts, lattice …

Asymmetric multiprotein complexes that undergo subunit exchange play central roles in
biology but present a challenge for design because the components must not only contain …

The de novo design of three protein chains that associate to form a heterotrimer (but not any
of the possible two-chain heterodimers) and that can drive the assembly of higher-order …

Computationally designed multi-subunit assemblies have shown considerable promise for
a variety of applications, including a new generation of potent vaccines. One of the major …

Computational protein design provides the tools to expand the diversity of protein complexes
beyond those found in nature. Understanding the rules that drive proteins to interact with …

A systematic and robust approach to generating complex protein nanomaterials would have
broad utility. We develop a hierarchical approach to designing multi-component protein …

Spider attachment disc silk fibers are spun into a viscous liquid that rapidly solidifies, gluing
dragline silk fibers to substrates for locomotion or web construction. Here we report the …