Promoting immune tolerance to transplanted organs can minimize the amount of
immunosuppressive drugs that patients need to take, reducing lifetime risks of mortality and …

The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic
acid (TCA) cycle that are engaged in epigenetic regulation of the chromatin function in the …

Previously, we reported that chromodomain Y–like (CDYL) acts as a crotonyl–coenzyme A
hydratase and negatively regulates histone crotonylation (Kcr). However, the global CDYL-…

Classical swine fever (CSF) caused by classical swine fever virus (CSFV) is one of the most
detrimental diseases, and leads to significant economic losses in the swine industry. Despite …

Naturally occurring cases of monogenic type 1 diabetes (T1D) help establish direct mechanisms
driving this complex autoimmune disease. A recently identified de novo germline gain-of…

Treg therapies are being tested in clinical trials in transplantation and autoimmune diseases,
however, the impact of inflammation on Tregs remains controversial. We challenged …

Alloantigen-specific regulatory T cell (Treg) therapy is a promising approach for suppressing
alloimmune responses and minimizing immunosuppression after solid organ transplantation…

The intrinsic regulation of programmed death ligand-1 (PD-L1) expression remains unclear.
Here, we report that zinc-finger protein 652 (ZNF652) is a potent transcription repressor of …

The chromatin-based rule governing the selection and activation of replication origins in
metazoans remains to be investigated. Here we report that NFIB, a member of Nuclear Factor I (…

Regulator of chromosome condensation domain-containing protein 1 (RCCD1), previously
reported as a partner of histone H3K36 demethylase KDM8 involved in chromosome …