Background Mycobacterium tuberculosis, the etiological agent of tuberculosis (TB), has the
ability to persist in its human host for exceptionally long periods of time. However, little is …

The Mycobacterium tuberculosis phoP mutant strain SO2 has previously been shown to have
reduced multiplication in mouse macrophages and in vivo using the mouse intravenous-…

The growth of Mycobacterium tuberculosis mutants unable to synthesize phthiocerol
dimycocerosates (DIMs) was recently shown to be impaired in mouse lungs. However, the precise …

Phospholipases C play a role in the pathogenesis of several bacteria. Mycobacterium
tuberculosis, the causative agent of tuberculosis, possesses four genes encoding putative …

Mycobacterium tuberculosis and other pathogenic mycobacterial species produce large
amounts of a glycogen‐like α‐glucan that represents the major polysaccharide of their …

Cell envelope lipids play an important role in the pathogenicity of mycobacteria, but the
mechanisms by which they are transported to the outer membrane of these prokaryotes are …

An ideal generic cancer immunotherapy should mobilize the immune system to destroy tumor
cells without harming healthy cells and remain active in case of recurrence. Furthermore, it …

Systemic toxicity currently prevents exploiting the huge potential of many cytokines for medical
applications. Here we present a novel strategy to engineer immunocytokines with very …

Langerin is a C-type lectin expressed by a subset of dendritic leukocytes, the Langerhans
cells (LC). Langerin is a cell surface receptor that induces the formation of an LC-specific …

Lipids that are found only in the cell envelope of pathogenic mycobacteria, such as those
containing multiple methyl-branched fatty acids, have long been thought to play a role in …