Importance Increasing evidence shows that physical activity is associated with reduced risk
for depression, pointing to a potential modifiable target for prevention. However, the causality …

Despite important advances from Genome Wide Association Studies (GWAS), for most
complex human traits and diseases, a sizable proportion of genetic variance remains …

Clinical presentation, outcomes, and duration of COVID-19 has ranged dramatically. While
some individuals recover quickly, others suffer from persistent symptoms, collectively known …

Despite rapid advances in genomic technology, our ability to account for phenotypic variation
using genetic information remains limited for many traits. This has unfortunately resulted in …

Background/objectives Physical activity (PA) protects against a wide range of diseases.
Habitual PA appears to be heritable, motivating the search for specific genetic variants that may …

A dramatic rise in obesity has occurred among humans within the last several decades. Little
is known about whether similar increases in obesity have occurred in animals inhabiting …

Sedentary behavior (SB) is associated with cardiometabolic disease and mortality, but its
association with dementia is currently unclear. This study investigates whether SB is …

Background Amyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative
disease. ALS is determined by gene-environment interactions and improved understanding of …

Background Air pollution may cause inflammatory and oxidative stress damage to the brain,
leading to neurodegenerative disease. The association between air pollution and dementia, …

The relationship between ethnicity and biology is of interest to anthropologists, biomedical
scientists, and historians in understanding how human groups are constructed. Ethnic self‐…