Germline mutations that activate genes in the canonical RAS/MAPK signaling pathway are
responsible for rare human developmental disorders known as RASopathies. Here, we …

Down syndrome is caused by trisomy of chromosome 21. To date, a multiplicity of mouse
models with Down-syndrome-related features has been developed to understand this complex …

Down syndrome (DS) is the most common example of a neurogenetic aneuploid disorder
leading to mental retardation. In most cases, DS results from an extra copy of human …

Down syndrome (DS) is one of the leading causes of intellectual disability, and patients with
DS face various health issues, including learning and memory deficits, congenital heart …

Fibroblasts are the major mesenchymal cell type in connective tissue and deposit the
collagen and elastic fibres of the extracellular matrix (ECM) 1 . Even within a single tissue, …

Background The mouse inbred line C57BL/6J is widely used in mouse genetics and its
genome has been incorporated into many genetic reference populations. More recently large …

Scope Trisomy for human chromosome 21 results in D own syndrome ( DS ), which is among
the most complex genetic perturbations leading to intellectual disability. Accumulating data …

Trisomy 21 is the most frequent genetic cause of cognitive impairment. To assess the
perturbations of gene expression in trisomy 21, and to eliminate the noise of genomic variability, …

Down syndrome (DS) is the most frequent genetic disorder leading to intellectual disabilities
and is caused by three copies of human chromosome 21. Mouse models are widely used to …

The role of sex in biomedical studies has often been overlooked, despite evidence of sexually
dimorphic effects in some biological studies. Here, we used high-throughput phenotype …