Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer's disease

Y Gerakis, C Hetz - The FEBS journal, 2018 - Wiley Online Library
Alzheimer's disease ( AD ) is a progressive neurodegenerative disease characterized by
synaptic dysfunction and accumulation of abnormal aggregates formed by amyloid‐β peptides …

Early development and molecular plasticity in the Mediterranean sea urchin Paracentrotus lividus exposed to CO2-driven acidification

…, S Dupont, C Castejon, Y Gerakis… - Journal of …, 2011 - journals.biologists.com
Ocean acidification is predicted to have significant effects on benthic calcifying invertebrates,
in particular on their early developmental stages. Echinoderm larvae could be particularly …

The UFMylation system in proteostasis and beyond

Y Gerakis, M Quintero, H Li, C Hetz - Trends in cell biology, 2019 - cell.com
Post-translational modifications are at the apex of cellular communication and eventually
regulate every aspect of life. The identification of new post-translational modifiers is opening …

Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging

…, G Martinez, AO Ardiles, DB Medinas, Y Gerakis… - The EMBO …, 2022 - embopress.org
Aging is a major risk factor to develop neurodegenerative diseases and is associated with
decreased buffering capacity of the proteostasis network. We investigated the significance of …

The unfolded protein response transcription factor XBP1s ameliorates Alzheimer's disease by improving synaptic function and proteostasis

…, G Tamburini, CMP Sabusap, Y Gerakis… - Molecular Therapy, 2023 - cell.com
Alteration in the buffering capacity of the proteostasis network is an emerging feature of
Alzheimer's disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress. The …

[HTML][HTML] Brain organoids: a next step for humanized Alzheimer's disease models?

Y Gerakis, C Hetz - Molecular Psychiatry, 2019 - nature.com
A major and actual issue in the field of neurodegenerative diseases is the poor translational
potential of most preclinical models [1]. In the context of Alzheimer’s disease (AD), a number …

[HTML][HTML] Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1

Y Gerakis, J Dunys, C Bauer, F Checler - Scientific Reports, 2016 - nature.com
The aspartyl protease β-site APP cleaving enzyme, BACE1, is the rate-limiting enzyme involved
in the production of amyloid-β peptide, which accumulates in both sporadic and familial …

Control of mammalian brain aging by the unfolded protein response (UPR)

…, G Tamburini, G Martinez, D Medinas, Y Gerakis… - Biorxiv, 2020 - biorxiv.org
Aging is the major risk factor for the development of dementia and neurodegenerative
disorders, and the aging brain manifests severe deficits in buffering capacity by the proteostasis …

A decay of the adaptive capacity of the unfolded protein response exacerbates Alzheimer's disease

Y Gerakis, C Hetz - Neurobiology of Aging, 2018 - Elsevier
Alterations in the buffering capacity of the proteostasis network are a salient feature of Alzheimer's
disease, associated with the occurrence of chronic endoplasmic reticulum (ER) stress. …

Control of mammalian brain ageing by the unfolded protein response transcription factor XBP1

…, G Tamburini, G Martinez, D Medinas, Y Gerakis… - 2020 - researchsquare.com
Brain ageing is the main risk factor to develop dementia and neurodegenerative diseases,
associated with a decay in the buffering capacity of the proteostasis network. We investigated …