User profiles for Yapeng Su
 | Yapeng SuFred Hutch Cancer Center Verified email at fredhutch.org Cited by 3271 |
[PDF][PDF] Multi-omics resolves a sharp disease-state shift between mild and moderate COVID-19
We present an integrated analysis of the clinical measurements, immune cells, and plasma
multi-omics of 139 COVID-19 patients representing all levels of disease severity, from serial …
multi-omics of 139 COVID-19 patients representing all levels of disease severity, from serial …
[PDF][PDF] Multiple early factors anticipate post-acute COVID-19 sequelae
Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However,
quantifiable risk factors for PASC and their biological associations are poorly resolved. We …
quantifiable risk factors for PASC and their biological associations are poorly resolved. We …
[HTML][HTML] Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line
The determination of individual cell trajectories through a high-dimensional cell-state space
is an outstanding challenge for understanding biological changes ranging from cellular …
is an outstanding challenge for understanding biological changes ranging from cellular …
Single cell proteomics in biomedicine: High‐dimensional data acquisition, visualization, and analysis
New insights on cellular heterogeneity in the last decade provoke the development of a
variety of single cell omics tools at a lightning pace. The resultant high‐dimensional single cell …
variety of single cell omics tools at a lightning pace. The resultant high‐dimensional single cell …
[HTML][HTML] Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19
A better understanding of the metabolic alterations in immune cells during severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may elucidate the wide diversity of …
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may elucidate the wide diversity of …
[PDF][PDF] Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19
…, HD Nischalke, CP Strassburg, E Stephenson, Y Su… - Immunity, 2021 - cell.com
Longitudinal analyses of the innate immune system, including the earliest time points, are
essential to understand the immunopathogenesis and clinical course of coronavirus disease (…
essential to understand the immunopathogenesis and clinical course of coronavirus disease (…
Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance
Continuous BRAF inhibition of BRAF mutant melanomas triggers a series of cell state
changes that lead to therapy resistance and escape from immune control before establishing …
changes that lead to therapy resistance and escape from immune control before establishing …
Epigenetic silencing of miR-125b is required for normal B-cell development
Deregulation of several microRNAs (miRs) can influence critical developmental checkpoints
during hematopoiesis as well as cell functions, eventually leading to the development of …
during hematopoiesis as well as cell functions, eventually leading to the development of …
[PDF][PDF] Single-cell phosphoproteomics resolves adaptive signaling dynamics and informs targeted combination therapy in glioblastoma
Intratumoral heterogeneity of signaling networks may contribute to targeted cancer therapy
resistance, including in the highly lethal brain cancer glioblastoma (GBM). We performed …
resistance, including in the highly lethal brain cancer glioblastoma (GBM). We performed …
[HTML][HTML] Raman-guided subcellular pharmaco-metabolomics for metastatic melanoma cells
Non-invasively probing metabolites within single live cells is highly desired but challenging.
Here we utilize Raman spectro-microscopy for spatial mapping of metabolites within single …
Here we utilize Raman spectro-microscopy for spatial mapping of metabolites within single …