Recently, modulation of immune checkpoints has risen to prominence as a means to treat a
number of solid malignancies, given the durable response seen in many patients and …

Toxoplasma gondii is an intracellular parasite that persistently infects the CNS and that has
genetically distinct strains which provoke different acute immune responses. How differences …

Glioblastoma (GBM) is the most common and deadliest form of brain tumor and remains
amongst the most difficult cancers to treat. Brevican (Bcan), a central nervous system (CNS)‐…

Glioblastoma (GBM) is one of the most lethal human tumors, and despite considerable advances
in multimodality treatments consisting of surgical removal, radiation and chemotherapy, …

High-grade gliomas are deadly cancers, and current standard-of-care has demonstrated
limited success. The ability to specifically target glioma cells can allow for the development of …

Background Targeted therapies for malignant brain cancer that are currently available have
little clinical activity, highlighting an urgent need for the development of novel precision …

Toxoplasma gondii is an obligate intracellular parasite that infects a wide range of intermediate
hosts, including humans and rodents. For both humans and rodents, once infected …

High-grade gliomas are deadly cancers, and current standard-of-care has demonstrated
limited success. The ability to specifically target glioma cells can allow for the development of …

… We also acknowledge Yarah Ghotmi for assistance in brain cryosections, Roscoe Wasserburg
for assistance with tissue culture, and Alex Mijalis for assistance in the synthesis of the …

Culture-based blood–brain barrier (BBB) models are crucial tools to enable rapid screening
of brain-penetrating drugs. However, reproducibility of in vitro barrier properties and …