User profiles for Yasemin Yozgat
 | Yasemin YOZGATIstanbul Medipol Universitesi Verified email at medipol.edu.tr Cited by 301 |
Oncogenic Kit signaling and therapeutic intervention in a mouse model of gastrointestinal stromal tumor
Kit receptor-activating mutations are critical in the pathogenesis of gastrointestinal stromal
tumors (GIST). We investigated mechanisms of oncogenic Kit signaling and the …
tumors (GIST). We investigated mechanisms of oncogenic Kit signaling and the …
Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor
Gastrointestinal stromal tumors (GISTs) predominantly harbor activating mutations in the
receptor tyrosine kinase KIT. To genetically dissect in vivo the requirement of different signal …
receptor tyrosine kinase KIT. To genetically dissect in vivo the requirement of different signal …
Imatinib upregulates compensatory integrin signaling in a mouse model of gastrointestinal stromal tumor and is more effective when combined with dasatinib
Activating mutations in the Kit receptor tyrosine kinase are associated with gastrointestinal
stromal tumor (GIST). Imatinib inhibits Kit and is front-line therapy for GIST. However, imatinib …
stromal tumor (GIST). Imatinib inhibits Kit and is front-line therapy for GIST. However, imatinib …
N-acetylcysteine suppresses colistimethate sodium-induced nephrotoxicity via activation of SOD2, eNOS, and MMP3 protein expressions
Objective: To investigate the molecular mechanisms of colistimethate sodium-induced
nephrotoxicity and the protective effect of N-acetylcysteine (NAC) against nephrotoxicity. Methods: …
nephrotoxicity and the protective effect of N-acetylcysteine (NAC) against nephrotoxicity. Methods: …
Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice
The clinical use of cisplatin, which is a first-line anticancer agent, is highly restricted due to
its adverse effects on kidneys that lead to nephrotoxicity. Therefore, some potential reno-…
its adverse effects on kidneys that lead to nephrotoxicity. Therefore, some potential reno-…
KIT receptor gain-of-function in hematopoiesis enhances stem cell self-renewal and promotes progenitor cell expansion
The KIT receptor tyrosine kinase has important roles in hematopoiesis. We have recently
produced a mouse model for imatinib resistant gastrointestinal stromal tumor (GIST) carrying …
produced a mouse model for imatinib resistant gastrointestinal stromal tumor (GIST) carrying …
Hexokinase 1b is a novel target for Non–small-cell lung cancer
Deregulation of glycolysis is common in non-small cell lung cancer (NSCLC). Hexokinase (HK)
enzymes catalyze the phosphoryl-group-transfer in glucose metabolism. There are a …
enzymes catalyze the phosphoryl-group-transfer in glucose metabolism. There are a …
Mediator-RNA Polymerase II Interactions Critical for Transcriptional Activation Are Mediated by the N-terminal Half of MED14 and C-terminal Domain of RPB1
Mediator is a large and evolutionarily conserved coactivator complex essential for RNA
polymerase II (Pol II)-mediated gene regulation at multiple steps of the transcription process, …
polymerase II (Pol II)-mediated gene regulation at multiple steps of the transcription process, …
Evaluation of cardiac arrhythmias by electrocardiographic markers in pediatric patients who have tuberous sclerosis without cardiac rhabdomyoma
Y Yozgat, HD Kus, FU Kahraman, M Yuksel, CK Firat… - Archives de …, 2021 - Elsevier
Background Tuberous sclerosis (TS) is an autosomal dominant and hereditary disorder.
Cardiac rhabdomyoma and arrhythmias are the most deleterious risk factors linked to TS. …
Cardiac rhabdomyoma and arrhythmias are the most deleterious risk factors linked to TS. …
p53-Regulated hexokinase 1b is a novel target for metabolic theraphy against non-small-cell lung cancer
Y Yozgat - 2019 - research.sabanciuniv.edu
Deregulation of glycolysis is common in non-small cell lung cancer (NSCLC). p53 controls
the cellular metabolism pathway by activating hexokinases (HKs) to increase glycolysis. HK …
the cellular metabolism pathway by activating hexokinases (HKs) to increase glycolysis. HK …