Objective: To investigate the impact of circulating histones on cardiac injury and dysfunction
in a murine model and patients with sepsis. Design: Prospective, observational clinical study …

Streptococcus pneumoniae accounts for more deaths worldwide than any other single
pathogen through diverse disease manifestations including pneumonia, sepsis and meningitis. …

Rationale: Neutrophil extracellular traps (NETs) are important in the host defense against
infection, but they also promote intravascular coagulation and multiorgan failure in animal …

Snake envenoming causes several potentially lethal pathologies. The specific pathology is
dictated by the toxin composition of venom, which varies by species, geography and …

Systemically sustained thrombin generation in vivo is the hallmark of disseminated intravascular
coagulation (DIC). Typically, this is in response to a progressing disease state that is …

… Alhamdi collected part of the clinical data. Drs. Yu, Wang, and Toh supervised the work and
wrote, edited, … Alhamdi has disclosed that he does not have any potential conflicts of interest. …

Thrombin generation is pivotal to both physiological blood clot formation and pathological
development of disseminated intravascular coagulation (DIC). In critical illness, extensive cell …

Disseminated intravascular coagulation (DIC) is an acquired condition that develops as a
complication of systemic and sustained cell injury in conditions such as sepsis and trauma. It …

… Alhamdi Y, Abrams ST, Lane S, Wang G, Toh C. Histone-Associated Thrombocytopenia
in Patients Who Are Critically Ill. JAMA. … Author Contributions: Drs Alhamdi and Toh had …

Microvascular thrombosis and blood–brain barrier (BBB) breakdown are key components of
cerebral malaria (CM) pathogenesis in African children and are implicated in fatal brain …