Two-component signal transduction as potential drug targets in pathogenic bacteria
Y Gotoh, Y Eguchi, T Watanabe, S Okamoto… - Current opinion in …, 2010 - Elsevier
Gene clusters contributing to processes such as cell growth and pathogenicity are often
controlled by two-component signal transduction systems (TCSs). Specific inhibitors against …
controlled by two-component signal transduction systems (TCSs). Specific inhibitors against …
Comparison of the sequencing bias of currently available library preparation kits for Illumina sequencing of bacterial genomes and metagenomes
…, Y Ogura, K Nakamura, R Nishida, Y Gotoh… - DNA …, 2019 - academic.oup.com
In bacterial genome and metagenome sequencing, Illumina sequencers are most frequently
used due to their high throughput capacity, and multiple library preparation kits have been …
used due to their high throughput capacity, and multiple library preparation kits have been …
[HTML][HTML] The Shiga toxin 2 production level in enterohemorrhagic Escherichia coli O157:H7 is correlated with the subtypes of toxin-encoding phage
…, T Mako, K Arisawa, K Katsura, T Ooka, Y Gotoh… - Scientific reports, 2015 - nature.com
Enterohemorrhagic E. coli (EHEC) causes diarrhea and hemorrhagic colitis with life-threatening
complications, such as hemolytic uremic syndrome. Their major virulence factor is Shiga …
complications, such as hemolytic uremic syndrome. Their major virulence factor is Shiga …
Defining the Genome Features of Escherichia albertii , an Emerging Enteropathogen Closely Related to Escherichia coli
…, K Yamaguchi, K Murase, Y Gotoh… - Genome biology and …, 2015 - academic.oup.com
Escherichia albertii is a recently recognized close relative of Escherichia coli . This emerging
enteropathogen possesses a type III secretion system (T3SS) encoded by the locus of …
enteropathogen possesses a type III secretion system (T3SS) encoded by the locus of …
Inhibitors targeting two-component signal transduction
T Watanabe, A Okada, Y Gotoh, R Utsumi - Bacterial signal transduction …, 2008 - Springer
A two-component signal transduction system (TCS) is an attractive target for antibacterial
agents. In this chapter, we review the TCS inhibitors developed during the past decade and …
agents. In this chapter, we review the TCS inhibitors developed during the past decade and …
[HTML][HTML] Single mutation makes Escherichia coli an insect mutualist
…, K Oguchi, R Okura, S Suzuki, Y Gotoh… - Nature …, 2022 - nature.com
Microorganisms often live in symbiosis with their hosts, and some are considered mutualists,
where all species involved benefit from the interaction. How free-living microorganisms …
where all species involved benefit from the interaction. How free-living microorganisms …
[HTML][HTML] Omics profiles of fecal and oral microbiota change in irritable bowel syndrome patients with diarrhea and symptom exacerbation
Background Irritable bowel syndrome (IBS) is a disorder of gut–brain interaction, including
dysregulation of the hypothalamic–pituitary–adrenal axis with salivary cortisol changes. …
dysregulation of the hypothalamic–pituitary–adrenal axis with salivary cortisol changes. …
[HTML][HTML] Colistin-resistant mcr-1–positive pathogenic Escherichia coli in swine, Japan, 2007− 2014
M Kusumoto, Y Ogura, Y Gotoh, T Iwata… - Emerging infectious …, 2016 - ncbi.nlm.nih.gov
Annotation of the sequence of SeCoV/GER/L00930/2012 performed on the basis of SeCoV/Italy/213306/2009
identified a similar putative coding sequence with a TGEV backbone and …
identified a similar putative coding sequence with a TGEV backbone and …
Evaluation of SNP calling methods for closely related bacterial isolates and a novel high-accuracy pipeline: BactSNP
D Yoshimura, R Kajitani, Y Gotoh… - Microbial …, 2019 - microbiologyresearch.org
Bacteria are highly diverse, even within a species; thus, there have been many studies which
classify a single species into multiple types and analyze the genetic differences between …
classify a single species into multiple types and analyze the genetic differences between …
Micro force sensor for intravascular neurosurgery and in vivo experiment
…, T Fukuda, H Iwata, K Itoigawa, Y Gotoh… - … MEMS 98. IEEE …, 1998 - ieeexplore.ieee.org
Catheter is one of the medical tools for endovascular surgeries, and it is frequently used for
neurosurgical operations. There is, however, a problem that doctors operate a catheter …
neurosurgical operations. There is, however, a problem that doctors operate a catheter …