Inactivation of constitutive autophagy results in formation of cytoplasmic protein inclusions
and leads to liver injury and neurodegeneration, but the details of abnormalities related to …

Impaired selective turnover of p62 by autophagy causes severe liver injury accompanied by
the formation of p62-positive inclusions and upregulation of detoxifying enzymes. These …

p62/Sqstm1 is a multifunctional protein involved in cell survival, growth and death, that is
degraded by autophagy. Amplification of the p62/Sqstm1 gene, and aberrant accumulation and …

DNA replication is spatially and temporally regulated during S‐phase. DNA replication timing
is established in early‐G1‐phase at a point referred to as timing decision point. However, …

Microenvironment-based alterations in phenotypes of mast cells influence the susceptibility
to anaphylaxis, yet the mechanisms underlying proper maturation of mast cells toward an …

Mutations in patatin-like phospholipase domain-containing 1 (PNPLA1) cause autosomal
recessive congenital ichthyosis, but the mechanism involved remains unclear. Here we show …

Metabolic disorders, including obesity and insulin resistance, have their basis in dysregulated
lipid metabolism and low-grade inflammation. In a microarray search of unique lipase-…

Epidermal lipids are important for skin homeostasis. However, the entire picture of the roles
of lipids, particularly nonceramide lipid species, in epidermal biology still remains obscure. …

Besides promoting inflammation by mobilizing lipid mediators, group IIA secreted phospholipase
A 2 (sPLA 2-IIA) prevents bacterial infection by degrading bacterial membranes. Here, …

Choline supplies methyl groups for regeneration of methionine and the methyl donor S-adenosylmethionine
in the liver. Here, we report that the catabolism of membrane …