Prospecting macroalgae (seaweeds) as feedstocks for bioconversion into biofuels and
commodity chemical compounds is limited primarily by the availability of tractable …

It is generally believed that proteins with promiscuous functions divergently evolved to acquire
higher specificity and activity 1 , 2 , 3 , 4 , 5 , and that this process was highly dependent …

To support an ever-increasing population, modern agriculture faces numerous challenges
that pose major threats to global food and energy security. Plant-associated microbes, with …

The increasing demands placed on natural resources for fuel and food production require that
we explore the use of efficient, sustainable feedstocks such as brown macroalgae. The full …

We describe a computationally designed enzyme, formolase (FLS), which catalyzes the
carboligation of three one-carbon formaldehyde molecules into one three-carbon …

Synthetic biological systems often require multiple, independently inducible promoters in
order to control the expression levels of several genes; however, cross talk between the …

We present 1,003 reference genomes that were sequenced as part of the Genomic Encyclopedia
of Bacteria and Archaea (GEBA) initiative, selected to maximize sequence coverage of …

Production of fine chemicals from heterologous pathways in microbial hosts is frequently
hindered by insufficient knowledge of the native metabolic pathway and its cognate enzymes; …

Diverse soil-resident bacteria can contribute to plant growth and health, but the molecular
mechanisms enabling them to effectively colonize their plant hosts remain poorly understood. …

Mono‐ and diterpenoids are of great industrial and medical value as specialty chemicals and
pharmaceuticals. Production of these compounds in microbial hosts, such as Escherichia …