A grand challenge in the post‐genomic era is a complete computer representation of the cell
and the organism, which will enable computational prediction of higher‐level complexity of …

The US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS,
formerly AERS) is a database that contains information on adverse event and medication error …

MicroRNAs (miRNAs) are small noncoding RNAs that negatively regulate protein-coding
genes. To identify miRNAs that have a tumor suppressive function in bladder cancer (BC), 156 …

Jet-lag symptoms arise from temporal misalignment between the internal circadian clock and
external solar time. We found that circadian rhythms of behavior (locomotor activity), clock …

Elucidation of both the three-dimensional structure and the dynamics of a protein is essential
to understand its function. Technical breakthroughs in single-particle analysis based on …

Cellular functions result from intricate networks of molecular interactions, which involve not
only proteins and nucleic acids but also small chemical compounds. Here we present an …

Malfunction of the circadian clock has been linked to the pathogenesis of a variety of
diseases. We show that mice lacking the core clock components Cryptochrome-1 (Cry1) and …

Osimertinib has been demonstrated to overcome the epidermal growth factor receptor (EGFR)-T790M,
the most relevant acquired resistance to first-generation EGFR–tyrosine kinase …

LIGAND is a composite database comprising three sections: COMPOUND for the information
about metabolites and other chemical compounds, REACTION for the collection of …

Purpose: The first-generation ALK tyrosine kinase inhibitor (TKI) crizotinib is a standard
therapy for patients with ALK-rearranged non–small cell lung cancer (NSCLC). Several next-…