The Wnt signalling pathway is essential for development and organogenesis 1, 2, 3. Wnt
signalling stabilizes β-catenin, which accumulates in the cytoplasm, binds to T-cell factor (TCF; …

The EP300 protein is a histone acetyltransferase 1, 2 that regulates transcription via chromatin
remodelling 3 and is important in the processes of cell proliferation 4 and differentiation 5. …

The histone H3 variant CenH3, called CENP-A in humans, is central in centromeric
chromatin to ensure proper chromosome segregation. In the absence of an underlying DNA …

We report genome-wide association studies for hematological and biochemical traits from ∼14,700
Japanese individuals. We identified 60 associations for 8 hematological traits and …

Gene expression profile analysis of lung and esophageal carcinomas revealed that Dikkopf-1
(DKK1) was highly transactivated in the great majority of lung cancers and esophageal …

Lung cancer is the most common cause of death from cancer worldwide, and its incidence
is increasing in East Asian and Western countries. To identify genetic factors that modify the …

The overwhelming majority of participants in current genetic studies are of European ancestry.
To elucidate disease biology in the East Asian population, we conducted a genome-wide …

Chronic hepatitis B is a serious infectious liver disease that often progresses to liver
cirrhosis and hepatocellular carcinoma; however, clinical outcomes after viral exposure vary …

In spite of a claim by KOBAYASHI (1990) that they do not correspond to the cells originally
depicted by CAJAL, a particular category of fibroblast-like cells have been identified in the gut …

We previously identified three novel HLA‐A24‐restricted epitope peptides, which were
derived from three cancer‐testis antigens, TTK protein kinase (TTK), lymphocyte antigen 6 …