BACKGROUND Biomolecular mechanisms are typically inferred from static structural “snapshots”
obtained by x-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, …

Background and Purpose— Cytochrome P450 epoxygenase metabolizes arachidonic acid
to epoxyeicosatrienoic acids (EETs). EETs are produced in the brain and perform important …

Initiation is a highly regulated, rate-limiting step in transcription. We used a series of approaches
to examine the kinetics of RNA polymerase (RNAP) transcription initiation in greater …

Over the past decade, fluorescence‐based single‐molecule studies significantly contributed
to characterizing the mechanism of RNA polymerase at different steps in transcription, …

Previous works have reported significant effects of macromolecular crowding on the structure
and behavior of biomolecules. The crowded intracellular environment, in contrast to in vitro …

Initiation is a highly regulated, rate-limiting step in transcription. We employed a series of
approaches to examine the kinetics of RNA polymerase (RNAP) transcription initiation in …

Biological reactions in the cellular environment differ physicochemically from those performed
in dilute buffer solutions due to, in part, slower diffusion of various components in the …

Tuesday, February 22, 2022 359a and replication processes. Due to its importance, RdRp
is one of the main targets for therapeutic approaches. We developed an in-vitro, single-…

Transcription of genomic DNA of all organisms is carried out by members of the multi-subunit
RNA polymerase family. Regulation of RNA polymerase localization and activity underlies …

Topics 1–Amyloid and Aggregation 2–Bioinformatics 3–Chaperones 4–Chemical Biology 5–Computational
Modeling/Simulation 6–Design/Engineering 7–Dynamics and Allostery 8–…