[HTML][HTML] Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
A new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
is the aetiological agent responsible for the 2019–2020 viral pneumonia outbreak of …
is the aetiological agent responsible for the 2019–2020 viral pneumonia outbreak of …
[HTML][HTML] Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease
…, J Shen, G Xiao, H Jiang, L Zhang, Y Ye, Y Xu - Nature …, 2021 - nature.com
The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) urgently needs an effective cure. 3CL …
respiratory syndrome coronavirus 2 (SARS-CoV-2) urgently needs an effective cure. 3CL …
What coronavirus 3C‐like protease tells us: from structure, substrate selectivity, to inhibitor design
The emergence of a variety of coronaviruses (CoVs) in the last decades has posed huge
threats to human health. Especially, the ongoing pandemic of coronavirus disease 2019 (…
threats to human health. Especially, the ongoing pandemic of coronavirus disease 2019 (…
Conformational transition of amyloid β-peptide
Y Xu, J Shen, X Luo, W Zhu, K Chen… - Proceedings of the …, 2005 - National Acad Sciences
The amyloid β-peptides (Aβs), containing 39–43 residues, are the key protein components of
amyloid deposits in Alzheimer's disease. To structurally characterize the dynamic behavior …
amyloid deposits in Alzheimer's disease. To structurally characterize the dynamic behavior …
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
The pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has become a global crisis. Replication of SARS-…
syndrome coronavirus 2 (SARS-CoV-2), has become a global crisis. Replication of SARS-…
[HTML][HTML] Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5
…, S Han, C Zhang, C Yi, X Chu, Y Zhu, Y Xu… - Nature …, 2021 - nature.com
The chemokine receptor CCR5 plays a vital role in immune surveillance and inflammation.
However, molecular details that govern its endogenous chemokine recognition and receptor …
However, molecular details that govern its endogenous chemokine recognition and receptor …
[HTML][HTML] Crystal structures of two phytohormone signal-transducing α/β hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14
Karrikins and strigolactones (SL) are two classes of butenolide compounds that control many
aspects of plant physiology. Karrikins, originally found in the smoke of forest fires, have the …
aspects of plant physiology. Karrikins, originally found in the smoke of forest fires, have the …
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
…, X Liu, G Xiao, H Jiang, Z Rao, LK Zhang, Y Xu… - Science, 2020 - science.org
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is the etiological agent
responsible for the global COVID-19 (coronavirus disease 2019) outbreak. The main protease of …
responsible for the global COVID-19 (coronavirus disease 2019) outbreak. The main protease of …
[HTML][HTML] Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19
…, Z Yi, B Hu, J Xu, X Gu, J Shen, Y Xu… - … England Journal of …, 2024 - Mass Medical Soc
Background Simnotrelvir is an oral 3-chymotrypsin–like protease inhibitor that has been
found to have in vitro activity against severe acute respiratory syndrome coronavirus 2 (SARS-…
found to have in vitro activity against severe acute respiratory syndrome coronavirus 2 (SARS-…
[HTML][HTML] Computational studies on acetylcholinesterases
Y Xu, S Cheng, JL Sussman, I Silman, H Jiang - Molecules, 2017 - mdpi.com
Functions of biomolecules, in particular enzymes, are usually modulated by structural
fluctuations. This is especially the case in a gated diffusion-controlled reaction catalyzed by an …
fluctuations. This is especially the case in a gated diffusion-controlled reaction catalyzed by an …