Bone marrow mesenchymal lineage cells are a heterogeneous cell population involved in
bone homeostasis and diseases such as osteoporosis. While it is long postulated that they …

Objective While transforming growth factor β (TGFβ) signaling plays a critical role in
chondrocyte metabolism, the TGFβ signaling pathways and target genes involved in cartilage …

The Segment Anything Model (SAM) is a recently developed large model for general-purpose
segmentation for computer vision tasks. SAM was trained using 11 million images with …

Focal radiotherapy is frequently associated with skeletal damage within the radiation field.
Our previous in vitro study showed that activation of Wnt/β‐catenin pathway can overcome …

C3-arylated indazole and pyrazoles are privileged structural motifs in agrochemicals and
pharmaceuticals. C-3 C–H arylation of (1H) indazole and pyrazole has been a significant …

Background Rats are a widely accepted preclinical model for evaluating intervertebral disc (IVD)
degeneration and regeneration. IVD morphology is commonly assessed using histology…

Cancer radiotherapy is often complicated by a spectrum of changes in the neighboring
bone from mild osteopenia to osteoradionecrosis. We previously reported that parathyroid …

Spinal conditions related to intervertebral disc (IVD) degeneration cost billions of dollars in
the US annually. Despite the prevalence and soaring cost, there is no specific treatment that …

Mice have been increasingly used as preclinical model to elucidate mechanisms and test
therapeutics for treating intervertebral disc degeneration (IDD). Several intervertebral disc (IVD…

Focal radiotherapy for cancer patients has detrimental effects on bones within the radiation
field and the primary clinical signs of bone damage include the loss of functional osteoblasts. …