Bacteria within biofilms secrete and surround themselves with an extracellular matrix, which
serves as a first line of defense against antibiotic attack. Polysaccharides constitute major …

The depletion of disruptive variation caused by purifying natural selection (constraint) has
been widely used to investigate protein-coding genes underlying human disorders, but …

Aromatic aldehydes are useful in numerous applications, especially as flavors, fragrances,
and pharmaceutical precursors. However, microbial synthesis of aldehydes is hindered by …

The depletion of disruptive variation caused by purifying natural selection (constraint) has
been widely used to investigate protein-coding genes underlying human disorders 1 , 2 , 3 – 4 …

… Yekaterina Tarasova … Wilson, Yekaterina Tarasova, William Phu, Riley Grant, Mary T.
Yohannes, Namrata Gupta, Irina M. Armean, Samantha M. … Yekaterina Tarasova …

Hyperthermophilic bacteria from the Thermotogales lineage can produce hydrogen by
fermenting a wide range of carbohydrates. Previous experimental studies identified a large …

The constitutive activation of the anoxic redox control transcriptional regulator (ArcA) in
Escherichia coli during aerobic growth, with the consequent production of a strain that exhibits …

3-hydroxy-γ-butyrolactone (3HBL) is a versatile chiral synthon, deemed a top value-added
chemical from biomass by the DOE. We recently reported the first biosynthetic pathway …

The generation of genome-scale data is becoming more routine, yet the subsequent analysis
of omics data remains a significant challenge. Here, an approach that integrates multiple …

Metabolic engineering efforts require enzymes that are both highly active and specific toward
the synthesis of a desired output product to be commercially feasible. The 3‐hydroxyacid (…