User profiles for Yen-Yu Ian Shih
Yen-Yu Ian ShihProfessor of Neurology, Director of Center for Animal MRI, University of North Carolina Verified email at unc.edu Cited by 3077 |
Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's …
Vascular pathology is a major feature of Alzheimer’s disease (AD) and other dementias. We
recently showed that chronic administration of the target-of-rapamycin (TOR) inhibitor …
recently showed that chronic administration of the target-of-rapamycin (TOR) inhibitor …
Chemogenetic stimulation of tonic locus coeruleus activity strengthens the default mode network
The default mode network (DMN) of the brain is functionally associated with a wide range of
behaviors. In this study, we used functional magnetic resonance imaging (fMRI), positron …
behaviors. In this study, we used functional magnetic resonance imaging (fMRI), positron …
[HTML][HTML] Optogenetic stimulation of anterior insular cortex neurons in male rats reveals causal mechanisms underlying suppression of the default mode network by the …
The salience network (SN) and default mode network (DMN) play a crucial role in cognitive
function. The SN, anchored in the anterior insular cortex (AI), has been hypothesized to …
function. The SN, anchored in the anterior insular cortex (AI), has been hypothesized to …
[HTML][HTML] Animal functional magnetic resonance imaging: trends and path toward standardization
Animal whole-brain functional magnetic resonance imaging (fMRI) provides a non-invasive
window into brain activity. A collection of associated methods aims to replicate observations …
window into brain activity. A collection of associated methods aims to replicate observations …
Adolescent alcohol exposure decreases frontostriatal resting‐state functional connectivity in adulthood
Connectivity of the prefrontal cortex (PFC) matures through adolescence, coinciding with
emergence of adult executive function and top‐down inhibitory control over behavior. Alcohol …
emergence of adult executive function and top‐down inhibitory control over behavior. Alcohol …
[HTML][HTML] Coordination of brain-wide activity dynamics by dopaminergic neurons
Several neuropsychiatric conditions, such as addiction and schizophrenia, may arise in part
from dysregulated activity of ventral tegmental area dopaminergic (TH VTA) neurons, as well …
from dysregulated activity of ventral tegmental area dopaminergic (TH VTA) neurons, as well …
Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli
The default mode network (DMN) is critical for self-referential mental processes, and its
dysfunction is implicated in many neuropsychiatric disorders. However, the neurophysiological …
dysfunction is implicated in many neuropsychiatric disorders. However, the neurophysiological …
Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth in mice
Alterations in genes that regulate brain size may contribute to both microcephaly and brain
tumor formation. Here, we report that Aspm, a gene that is mutated in familial microcephaly, …
tumor formation. Here, we report that Aspm, a gene that is mutated in familial microcephaly, …
[HTML][HTML] Automatic skull stripping of rat and mouse brain MRI data using U-Net
Accurate removal of magnetic resonance imaging (MRI) signal outside the brain, aka, skull
stripping, is a key step in the brain image pre-processing pipelines. In rodents, this is mostly …
stripping, is a key step in the brain image pre-processing pipelines. In rodents, this is mostly …
Supramammillary nucleus synchronizes with dentate gyrus to regulate spatial memory retrieval through glutamate release
The supramammillary nucleus (SuM) provides substantial innervation to the dentate gyrus (DG).
It remains unknown how the SuM and DG coordinate their activities at the circuit level to …
It remains unknown how the SuM and DG coordinate their activities at the circuit level to …