User profiles for Yen-Yu Ian Shih

Yen-Yu Ian Shih

Professor of Neurology, Director of Center for Animal MRI, University of North Carolina
Verified email at unc.edu
Cited by 3077

Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's …

…, MJ Hart, M Javors, YYI Shih… - Journal of Cerebral …, 2013 - journals.sagepub.com
Vascular pathology is a major feature of Alzheimer’s disease (AD) and other dementias. We
recently showed that chronic administration of the target-of-rapamycin (TOR) inhibitor …

Chemogenetic stimulation of tonic locus coeruleus activity strengthens the default mode network

…, H Yuan, SH Lee, G Cui, P Jensen, YYI Shih - Science …, 2022 - science.org
The default mode network (DMN) of the brain is functionally associated with a wide range of
behaviors. In this study, we used functional magnetic resonance imaging (fMRI), positron …

[HTML][HTML] Optogenetic stimulation of anterior insular cortex neurons in male rats reveals causal mechanisms underlying suppression of the default mode network by the …

…, D Cerri, B Lee, R Yuan, SH Lee, YYI Shih - Nature …, 2023 - nature.com
The salience network (SN) and default mode network (DMN) play a crucial role in cognitive
function. The SN, anchored in the anterior insular cortex (AI), has been hypothesized to …

[HTML][HTML] Animal functional magnetic resonance imaging: trends and path toward standardization

…, A Hess, SD Keilholz, JP Lerch, YYI Shih… - Frontiers in …, 2020 - frontiersin.org
Animal whole-brain functional magnetic resonance imaging (fMRI) provides a non-invasive
window into brain activity. A collection of associated methods aims to replicate observations …

Adolescent alcohol exposure decreases frontostriatal resting‐state functional connectivity in adulthood

…, H Zhu, FT Crews, DL Robinson, YYI Shih - Addiction …, 2018 - Wiley Online Library
Connectivity of the prefrontal cortex (PFC) matures through adolescence, coinciding with
emergence of adult executive function and top‐down inhibitory control over behavior. Alcohol …

[HTML][HTML] Coordination of brain-wide activity dynamics by dopaminergic neurons

…, M Das, IB Witten, K Deisseroth, YYI Shih… - …, 2017 - nature.com
Several neuropsychiatric conditions, such as addiction and schizophrenia, may arise in part
from dysregulated activity of ventral tegmental area dopaminergic (TH VTA) neurons, as well …

Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli

…, TWW Wang, S Ryali, V Menon, YYI Shih - Science …, 2023 - science.org
The default mode network (DMN) is critical for self-referential mental processes, and its
dysfunction is implicated in many neuropsychiatric disorders. However, the neurophysiological …

Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth in mice

…, K Veleta, EA Oyarzabal, JR Merrill, YYI Shih… - …, 2015 - journals.biologists.com
Alterations in genes that regulate brain size may contribute to both microcephaly and brain
tumor formation. Here, we report that Aspm, a gene that is mutated in familial microcephaly, …

[HTML][HTML] Automatic skull stripping of rat and mouse brain MRI data using U-Net

…, MA Broadwater, SH Lee, D Shen, YYI Shih - Frontiers in …, 2020 - frontiersin.org
Accurate removal of magnetic resonance imaging (MRI) signal outside the brain, aka, skull
stripping, is a key step in the brain image pre-processing pipelines. In rodents, this is mostly …

Supramammillary nucleus synchronizes with dentate gyrus to regulate spatial memory retrieval through glutamate release

…, L Quintanilla, I Wickersham, M Lazarus, YYI Shih… - elife, 2020 - elifesciences.org
The supramammillary nucleus (SuM) provides substantial innervation to the dentate gyrus (DG).
It remains unknown how the SuM and DG coordinate their activities at the circuit level to …