Background Atopic dermatitis (AD) shows very high prevalence in Asia, with a large unmet
need for effective therapeutics. Direct comparisons between European American (EA) and …

Background Atopic dermatitis (AD) affects 15% to 25% of children and 4% to 7% of adults.
Paradigm-shifting discoveries about AD have been based on adult biomarkers, reflecting …

Background Genomic profiling of lesional and nonlesional skin of patients with atopic dermatitis
(AD) using microarrays has led to increased understanding of AD and identification of …

Background Allergic contact dermatitis (ACD) is the most common occupational disease.
Although murine contact hypersensitivity provides a framework for understanding ACD, it …

Background The molecular signature of atopic dermatitis (AD) lesions is associated with T H
2 and T H 22 activation and epidermal alterations. However, the epidermal and dermal AD …

Background Although atopic dermatitis (AD) often starts in early childhood, detailed tissue
profiling of early-onset AD in children is lacking, hindering therapeutic development for this …

Background Alopecia areata (AA) is a common T cell–mediated disorder with limited
therapeutics. A molecular profile of cytokine pathways in AA tissues is lacking. Although studies …

… , Riana Dutt ScB a c , Robert Finney MD e , Nikhil Dhingra MD c , Peng Xiangyu MSc a c ,
Hui Xu MSc a c , Yeriel D. Estrada BS c , Xiuzhong Zheng MSc a , Patricia Gilleaudeau NP a , …

Background The ichthyoses are rare genetic disorders associated with generalized scaling,
erythema, and epidermal barrier impairment. Pathogenesis-based therapy is largely lacking …

Background GBR 830 is a humanized mAb against OX40, a costimulatory receptor on
activated T cells. OX40 inhibition might have a therapeutic role in T cell–mediated diseases, …