Micro- or nanofiber-based materials have extensive applications in biomedical fields due to
their capability to mimic many aspects of physiological microenvironment in vivo. Fabricating …

Microfluidic technologies have recently been shown to hold significant potential as novel
tools for producing micro- and nano-scale structures for a variety of applications in tissue …

Reconstruction of skin equivalents with physiologically relevant cellular and matrix architecture
is indispensable for basic research and industrial applications. As skin-nerve crosstalk is …

Pancreatic islet transplantation is a promising method for treatment of type 1 diabetes
mellitus. However, transplanted islets can be destroyed due to host immune reactions. To …

Native pancreatic islets interact with neighboring cells by establishing three-dimensional (3D)
structures, and are surrounded by perfusion at an interstitial flow level. However, flow …

Type 1 diabetes mellitus (T1DM) is a chronic disorder characterized by targeted
autoimmune-mediated destruction of the β cells of Langerhans within pancreatic islets. Currently, …

Here, a spheroidal 3D co-culture model of primary (rat) pancreatic islets and hepatocytes with
uniform size and shape was developed using hemispheric concave microwell arrays. We …

Placenta-derived mesenchymal stem cells (PD-MSCs) have numerous advantages over other
adult MSCs that make them an attractive cell source for regenerative medicine. Here, we …

Sensing devices have shown tremendous potential for monitoring state-of-the-art organ chip
devices. However, challenges like miniaturization while maintaining higher performance, …

Embryonic stem cells (ESCs) are pluripotent and capable of self‐renewal. ESC aggregates,
termed embryoid bodies (EBs), have been widely adopted as an in vitro differentiation model…