Tissues derive ATP from two pathways—glycolysis and the tricarboxylic acid (TCA) cycle
coupled to the electron transport chain. Most energy in mammals is produced via TCA …

There is increasing evidence that oncogenic transformation modifies the metabolic program
of cells. A common alteration is the upregulation of glycolysis, and efforts to target glycolytic …

Rapamycin, an inhibitor of the mechanistic target of rapamycin (m TOR ), robustly extends the
lifespan of model organisms including mice. We recently found that chronic treatment with …

How adult tissue stem and niche cells respond to the nutritional state of an organism is not
well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal …

Cells require a constant supply of fatty acids to survive and proliferate. Fatty acids incorporate
into membrane and storage glycerolipids through a series of endoplasmic reticulum (ER) …

The novel nucleotide oligomerization domain (NOD)-like receptor (NLR) with a caspase
activation and recruitment domain (CARD) 3 (NLRC3) protein belongs to the NLR family of …

Metastases arise from a subset of cancer cells that disseminate from the primary tumor;
however, the factors that contribute to proliferation of cancer cells in a secondary site are …

Behçet’s syndrome (BS) is a systemic inflammatory disorder with unknown etiology. Features
of both innate and adaptive immunity have been claimed in the pathogenesis of BS. To test …

Altered metabolism is a hallmark of cancer that reflects the increased energetic and
biosynthetic demands of proliferating cancer cells. Accumulating evidence suggests that many …

Self-renewal of intestinal stem cells is controlled by Wingless/Wnt-β catenin signaling in
both Drosophila and mammals. As Axin is a rate-limiting factor in Wingless signaling, its …