CCR4-NOT is a conserved multiprotein complex which regulates eukaryotic gene expression
principally via shortening of poly(A) tails of messenger RNA or deadenylation. Here, we …

Viruses from the genus Enterovirus are important human pathogens. Receptor binding or
exposure to acidic pH in endosomes converts enterovirus particles to an activated state that is …

Pumilio paralogs, PUM1 and PUM2, are sequence-specific RNA-binding proteins that are
essential for vertebrate development and neurological functions. PUM1&2 negatively regulate …

The CCR4-NOT complex acts as a central player in the control of mRNA turnover and mediates
accelerated mRNA degradation upon HDAC inhibition. Here, we explored acetylation-…

XRN1 is the major cytoplasmic exoribonuclease in eukaryotes, which degrades deadenylated
and decapped mRNAs in the last step of the 5′–3′ mRNA decay pathway. Metazoan …

Pumilio is an RNA-binding protein that represses a network of mRNAs to control embryogenesis,
stem cell fate, fertility and neurological functions in Drosophila. We sought to identify …

Shortening of messenger RNA poly(A) tails, or deadenylation, is a rate-limiting step in
mRNA decay and is highly regulated during gene expression. The incorporation of non-…

NOT1, NOT10, and NOT11 form a conserved module in the CCR4-NOT complex, critical for
post-transcriptional regulation in eukaryotes, but how this module contributes to the functions …

The western honeybee ( Apis mellifera ) is the most important commercial insect pollinator.
However, bees are under pressure from habitat loss, environmental stress, and pathogens, …

Developing an effective mRNA therapeutic often requires maximizing protein output per
delivered mRNA molecule. We previously found that coding sequence (CDS) design can …