Overexpression of DNA 5′-cytosine-methyltransferases (DNMT), which are enzymes that
methylate the cytosine residue of CpGs, is involved in many cancers. However, the …

Renal cell carcinoma ( RCC ) is the most lethal of all urological malignancies because of its
potent metastasis potential. Melatonin exerts multiple tumor‐suppressing activities through …

Wnt/β‐catenin signaling is frequently activated in advanced prostate cancer and contributes
to therapy resistance and metastasis. However, activating mutations in the Wnt/β‐catenin …

Glass-to-glass transitions are useful for us to understand the glass nature, but it remains
difficult to tune the metallic glass into significantly different glass states. Here, we have …

The aldolase family members involved in metabolism and glycolysis are present in three
isoforms: ALDOA, ALDOB, and ALDOC. Aldolases are differentially expressed in human tissues…

Background The epidermal growth factor receptor (EGFR) plays important roles in cell
survival, growth, differentiation, and tumorigenesis. Dysregulation of the EGFR is a common …

Background Prostate cancer (PCa) is considered one of the most prevalent malignancy
globally, and metastasis is a major cause of death. Apigenin (API) is a dietary flavonoid which …

Pyruvate kinase muscle isozymes (PKMs) have crucial roles in regulating metabolic
changes during carcinogenesis. A switch from PKM1 to PKM2 isoform was thought to lead to …

Cancer cells encounter metabolic stresses such as hypoxia and nutrient limitations because
they grow and divide more quickly than their normal counterparts. In response to glucose …

Background Cisplatin is the first-line chemotherapy used against most upper aerodigestive
tract carcinomas. In head and neck cancer, sensitivity to cisplatin remains the key issue in …