User profiles for Yi-Nan Zhang

Yi-Nan Zhang

Staff Scientist, The Scripps Research Institute
Verified email at scripps.edu
Cited by 4635

Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination

YN Zhang, W Poon, AJ Tavares, ID McGilvray… - Journal of controlled …, 2016 - Elsevier
30–99% of administered nanoparticles will accumulate and sequester in the liver after
administration into the body. This results in reduced delivery to the targeted diseased tissue and …

Thulium laser versus standard transurethral resection of the prostate: a randomized prospective trial

SJ Xia, J Zhuo, XW Sun, BM Han, Y Shao, YN Zhang - European urology, 2008 - Elsevier
OBJECTIVE: Thulium laser resection of the prostate-tangerine technique (TmLRP-TT) is a
transurethral procedure that uses thulium laser fiber to dissect whole prostatic lobes off the …

The dose threshold for nanoparticle tumour delivery

B Ouyang, W Poon, YN Zhang, ZP Lin, BR Kingston… - Nature materials, 2020 - nature.com
Nanoparticle delivery to solid tumours over the past ten years has stagnated at a median of
0.7% of the injected dose. Varying nanoparticle designs and strategies have yielded only …

Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities

YN Zhang, W Zhang, D Hong, L Shi, Q Shen… - Bioorganic & medicinal …, 2008 - Elsevier
Protein tyrosine phosphatase 1B is a key factor in the negative regulation of insulin pathway
and a promising target for treatment of diabetes and obesity. Herein, a series of competitive …

Elimination pathways of nanoparticles

W Poon, YN Zhang, B Ouyang, BR Kingston, JLY Wu… - ACS …, 2019 - ACS Publications
Understanding how nanoparticles are eliminated from the body is required for their
successful clinical translation. Many promising nanoparticle formulations for in vivo medical …

Engineering a highly elastic human protein–based sealant for surgical applications

N Annabi, YN Zhang, A Assmann, ES Sani… - Science translational …, 2017 - science.org
Surgical sealants have been used for sealing or reconnecting ruptured tissues but often
have low adhesion, inappropriate mechanical strength, cytotoxicity concerns, and poor …

Effect of removing Kupffer cells on nanoparticle tumor delivery

AJ Tavares, W Poon, YN Zhang, Q Dai… - Proceedings of the …, 2017 - National Acad Sciences
A recent metaanalysis shows that 0.7% of nanoparticles are delivered to solid tumors. This
low delivery efficiency has major implications in the translation of cancer nanomedicines, as …

A highly elastic and rapidly crosslinkable elastin‐like polypeptide‐based hydrogel for biomedical applications

YN Zhang, RK Avery, Q Vallmajo‐Martin… - Advanced functional …, 2015 - Wiley Online Library
Elastin‐like polypeptides (ELPs) are promising for biomedical applications due to their
unique thermoresponsive and elastic properties. ELP‐based hydrogels have been produced …

The biology and ecology of the emerald ash borer, Agrilus planipennis, in China

XY Wang, ZQ Yang, JR Gould, YN Zhang… - Journal of insect …, 2010 - academic.oup.com
The biology, ecology, and life cycle of the emerald ash borer, Agrilus planipennis Fairmaire (Coleoptera:
Buprestidae), were studied using regular inspection in the forest and …

Nanoparticle size influences antigen retention and presentation in lymph node follicles for humoral immunity

YN Zhang, J Lazarovits, W Poon, B Ouyang… - Nano …, 2019 - ACS Publications
Lymph node follicles capture and retain antigens to induce germinal centers and long-lived
humoral immunity. However, control over antigen retention has been limited. Here we …