MIF signal transduction initiated by binding to CD74
…, S Donnelly, J Baugh, T Delohery, Y Chen… - The Journal of …, 2003 - rupress.org
Macrophage migration inhibitory factor (MIF) accounts for one of the first cytokine activities
to have been described, and it has emerged recently to be an important regulator of innate …
to have been described, and it has emerged recently to be an important regulator of innate …
Toll-like receptors on tumor cells facilitate evasion of immune surveillance
B Huang, J Zhao, H Li, KL He, Y Chen, L Mayer… - Cancer research, 2005 - AACR
The signal pathways that trigger tumor cell escape from immune surveillance are incompletely
understood. Toll-like receptors (TLRs), which activate innate and adaptive immune …
understood. Toll-like receptors (TLRs), which activate innate and adaptive immune …
[HTML][HTML] Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and …
S Liu, G Xiao, Y Chen, Y He, J Niu, CR Escalante… - The Lancet, 2004 - thelancet.com
Background Studies on the fusion-inhibitory peptides derived from the heptad repeat 1 and
2 (HR1 and HR2) regions of the HIV-1 envelope glycoprotein gp41 provided crucial …
2 (HR1 and HR2) regions of the HIV-1 envelope glycoprotein gp41 provided crucial …
The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF)
…, W Schulte, J Fan, H Lue, Y Chen… - Proceedings of the …, 2011 - National Acad Sciences
Macrophage migration inhibitory factor (MIF) is a pivotal regulator of the immune response.
Neutralization or genetic deletion of MIF does not completely abrogate activation responses, …
Neutralization or genetic deletion of MIF does not completely abrogate activation responses, …
A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF …
…, H Lue, X Du, A Liu, H Xiong, Y Chen… - … and cellular biology, 2009 - Am Soc Microbiol
Macrophage migration-inhibitory factor (MIF) is an upstream regulator of innate immunity
and a potential molecular link between inflammation and cancer. The unusual structural …
and a potential molecular link between inflammation and cancer. The unusual structural …
Adenylyl cyclase 6 is selectively regulated by protein kinase A phosphorylation in a region involved in Gαs stimulation
Y Chen, A Harry, J Li, MJ Smit, X Bai… - Proceedings of the …, 1997 - National Acad Sciences
Receptors activate adenylyl cyclases through the Gα s subunit. Previous studies from our
laboratory have shown in certain cell types that express adenylyl cyclase 6 (AC6), …
laboratory have shown in certain cell types that express adenylyl cyclase 6 (AC6), …
Systems pharmacology of adverse event mitigation by drug combinations
S Zhao, T Nishimura, Y Chen, EU Azeloglu… - Science translational …, 2013 - science.org
Drugs are designed for therapy, but medication-related adverse events are common, and
risk/benefit analysis is critical for determining clinical use. Rosiglitazone, an efficacious …
risk/benefit analysis is critical for determining clinical use. Rosiglitazone, an efficacious …
Inhibition of the JAK/STAT pathway with ruxolitinib overcomes cisplatin resistance in non-small-cell lung cancer NSCLC
Y Hu, Y Hong, YJ Xu, P Liu, DH Guo, Y Chen - Apoptosis, 2014 - Springer
This study was aimed to elucidate the roles of inhibition of related JAK/STAT pathways in
regulating cytotoxicity induced by cisplatin in non-small-cell lung cancer (NSCLC) cell. We …
regulating cytotoxicity induced by cisplatin in non-small-cell lung cancer (NSCLC) cell. We …
A Leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses
…, M Merk, RA Mitchell, J Trent, Y Chen… - The Journal of …, 2008 - journals.aai.org
Parasitic organisms have evolved specialized strategies to evade immune defense mechanisms.
We describe herein an ortholog of the cytokine, macrophage migration inhibitory factor (…
We describe herein an ortholog of the cytokine, macrophage migration inhibitory factor (…
[HTML][HTML] Structural and functional characterization of a secreted hookworm macrophage migration inhibitory factor (MIF) that interacts with the human MIF receptor …
…, LM Harrison, H Xiong, YKA Kwong, Y Chen… - Journal of Biological …, 2007 - ASBMB
Hookworms, parasitic nematodes that infect nearly one billion people worldwide, are a major
cause of anemia and malnutrition. We hypothesize that hookworms actively manipulate the …
cause of anemia and malnutrition. We hypothesize that hookworms actively manipulate the …