Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types
Recombinant adeno-associated viruses (rAAVs) are efficient gene delivery vectors via
intravenous delivery; however, natural serotypes display a finite set of tropisms. To expand their …
intravenous delivery; however, natural serotypes display a finite set of tropisms. To expand their …
Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing
Small noncoding RNAs that associate with Piwi proteins, called piRNAs, serve as guides for
repression of diverse transposable elements in germ cells of metazoa. In Drosophila, the …
repression of diverse transposable elements in germ cells of metazoa. In Drosophila, the …
Panoramix enforces piRNA-dependent cotranscriptional silencing
The Piwi-interacting RNA (piRNA) pathway is a small RNA–based innate immune system
that defends germ cell genomes against transposons. In Drosophila ovaries, the nuclear Piwi …
that defends germ cell genomes against transposons. In Drosophila ovaries, the nuclear Piwi …
[PDF][PDF] A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila
A large fraction of our genome consists of mobile genetic elements. Governing transposons
in germ cells is critically important, and failure to do so compromises genome integrity, …
in germ cells is critically important, and failure to do so compromises genome integrity, …
T cell antigen discovery via trogocytosis
T cell receptor (TCR) ligand discovery is essential for understanding and manipulating
immune responses to tumors. We developed a cell-based selection platform for TCR ligand …
immune responses to tumors. We developed a cell-based selection platform for TCR ligand …
Chessgpt: Bridging policy learning and language modeling
When solving decision-making tasks, humans typically depend on information from two key
sources:(1) Historical policy data, which provides interaction replay from the environment, …
sources:(1) Historical policy data, which provides interaction replay from the environment, …
[PDF][PDF] Cutoff suppresses RNA polymerase II termination to ensure expression of piRNA precursors
Small non-coding RNAs called piRNAs serve as guides for an adaptable immune system
that represses transposable elements in germ cells of Metazoa. In Drosophila the RDC …
that represses transposable elements in germ cells of Metazoa. In Drosophila the RDC …
[PDF][PDF] Su (var) 2-10 and the SUMO pathway link piRNA-guided target recognition to chromatin silencing
Regulation of transcription is the main mechanism responsible for precise control of gene
expression. Whereas the majority of transcriptional regulation is mediated by DNA-binding …
expression. Whereas the majority of transcriptional regulation is mediated by DNA-binding …
Splicing-independent loading of TREX on nascent RNA is required for efficient expression of dual-strand piRNA clusters in Drosophila
The conserved THO/TREX (transcription/export) complex is critical for pre-mRNA processing
and mRNA nuclear export. In metazoa, TREX is loaded on nascent RNA transcribed by …
and mRNA nuclear export. In metazoa, TREX is loaded on nascent RNA transcribed by …
Minotaur is critical for primary piRNA biogenesis
Piwi proteins and their associated small RNAs are essential for fertility in animals. In part,
this is due to their roles in guarding germ cell genomes against the activity of mobile genetic …
this is due to their roles in guarding germ cell genomes against the activity of mobile genetic …