… Drubin, Yidi Sun; Clathrin-mediated endocytosis in budding yeast at a glance. J Cell Sci 15
… continuously streams inwards from these coat proteins (Sun and Drubin, 2013). The Epsin N-…

In budding yeast, many proteins involved in endocytic internalization, including adaptors and
actin cytoskeletal proteins, are localized to cortical patches of differing protein composition. …

Genome editing holds promise for correcting pathogenic mutations. However, it is difficult to
determine off-target effects of editing due to single-nucleotide polymorphism in individuals. …

Recently developed DNA base editing methods enable the direct generation of desired point
mutations in genomic DNA without generating any double-strand breaks 1 , 2 – 3 , but the …

Conversion of glial cells into functional neurons represents a potential therapeutic approach
for replenishing neuronal loss associated with neurodegenerative diseases and brain injury…

Actin polymerization essential for endocytic internalization in budding yeast is controlled by
four nucleation promoting factors (NPFs) that each exhibits a unique dynamic behavior at …

Endocytic vesicle formation is a complex process that couples sequential protein recruitment
and lipid modifications with dramatic shape transformations of the plasma membrane. …

Despite rapid progresses in the genome-editing field, in vivo simultaneous overexpression of
multiple genes remains challenging. We generated a transgenic mouse using an improved …

Human stem cell-derived blastoids display similar morphology and cell lineages to normal
blastocysts. However, the ability to investigate their developmental potential is limited. Here, …

Organoid models have the potential to recapitulate the biological and pharmacotypic features
of parental tumors. Nevertheless, integrative pharmaco-proteogenomics analysis for drug …