… Yifan Cheng … Shawn Q Zheng, Yifan Cheng & David A Agard … Yifan Cheng …

Transient receptor potential (TRP) channels are sensors for a wide range of cellular and
environmental signals, but elucidating how these channels respond to physical and chemical …

Until only a few years ago, single-particle electron cryo-microscopy (cryo-EM) was usually
not the first choice for many structural biologists due to its limited resolution in the range of …

Cryo–electron microscopy, or simply cryo-EM, refers mainly to three very different yet
closely related techniques: electron crystallography, single-particle cryo-EM, and electron …

In recent work with large high-symmetry viruses, single-particle electron cryomicroscopy (cryo-EM)
has achieved the determination of near-atomic-resolution structures by allowing …

The TRPA1 ion channel (also known as the wasabi receptor) is a detector of noxious chemical
agents encountered in our environment or produced endogenously during tissue injury or …

Iron, insoluble as free Fe 3+ and toxic as free Fe 2+ , is distributed through the body as Fe 3+
bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin …

Cryo-electron microscopy (cryo-EM) of single-particle specimens is used to determine the
structure of proteins and macromolecular complexes without the need for crystals. Recent …

Transient receptor potential (TRP) channels are polymodal signal detectors that respond to
a wide range of physical and chemical stimuli. Elucidating how these channels integrate and …

Substrates enter the cylindrical 20S proteasome through a gated channel that is regulated
by the ATPases in the 19S regulatory particle in eukaryotes or the homologous PAN ATPase …