Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion

…, D Jhutty, CM Nemec, J Wang, L Wang, Y Yin… - Nature …, 2019 - nature.com
Understanding complex tissues requires single-cell deconstruction of gene regulation with
precision and scale. Here, we assess the performance of a massively parallel droplet-based …

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex

…, MN Tran, Z Besich, M Tippani, J Chew, Y Yin… - BioRxiv, 2020 - biorxiv.org
We used the 10x Genomics Visium platform to define the spatial topography of gene expression
in the six-layered human dorsolateral prefrontal cortex (DLPFC). We identified extensive …

GeoChip 3.0 as a high-throughput tool for analyzing microbial community composition, structure and functional activity

…, M Xu, CL Hemme, X Li, L Wu, TJ Gentry, Y Yin… - The ISME …, 2010 - academic.oup.com
A new generation of functional gene arrays (FGAs; GeoChip 3.0) has been developed, with
∼28 000 probes covering approximately 57 000 gene variants from 292 functional gene …

[HTML][HTML] LoAdaBoost: Loss-based AdaBoost federated machine learning with reduced computational complexity on IID and non-IID intensive care data

L Huang, Y Yin, Z Fu, S Zhang, H Deng, D Liu - Plos one, 2020 - journals.plos.org
Intensive care data are valuable for improvement of health care, policy making and many
other purposes. Vast amount of such data are stored in different locations, on many different …

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex

…, MN Tran, Z Besich, M Tippani, J Chew, Y Yin… - Nature …, 2021 - nature.com
We used the 10x Genomics Visium platform to define the spatial topography of gene expression
in the six-layered human dorsolateral prefrontal cortex. We identified extensive layer-…

Prediction algorithm for network security situation based on bp neural network optimized by sa-soa

R Zhang, M Liu, Y Yin, Q Zhang, Z Cai - International Journal of …, 2020 - ijpe-online.com
Abstract: Network security situation prediction has been a major research focus in the field
of network security in recent years. It can predict the future network security status and its …

[HTML][HTML] Single-cell sequencing of genomic DNA resolves sub-clonal heterogeneity in a melanoma cell line

…, J Sorenson, IT Fiddes, V Kumar, Y Yin… - Communications …, 2020 - nature.com
We performed shallow single-cell sequencing of genomic DNA across 1475 cells from a cell-line,
COLO829, to resolve overall complexity and clonality. This melanoma tumor-line has …

Identification of functional paralog shift mutations: Conversion of Escherichia coli malate dehydrogenase to a lactate dehydrogenase

Y Yin, JF Kirsch - Proceedings of the National Academy of …, 2007 - National Acad Sciences
Five positions in the Escherichia coli malate dehydrogenase (eMDH) sequence, which
distinguish MDH from lactate dehydrogenase (LDH) activity, were identified through a …

[HTML][HTML] Sc-compReg enables the comparison of gene regulatory networks between conditions using single-cell data

…, J Xin, F Meschi, ML Li, CM Nemec, Y Yin… - Nature …, 2021 - nature.com
The comparison of gene regulatory networks between diseased versus healthy individuals
or between two different treatments is an important scientific problem. Here, we propose sc-…

Comparison of primary suture and T-tube drainage after laparoscopic common bile duct exploration combined with intraoperative choledochoscopy in the treatment of …

Y Yin, K He, X Xia - Journal of Laparoendoscopic & Advanced …, 2022 - liebertpub.com
Objective: To compare the safety and feasibility of T-tube drainage and primary suture after
laparoscopy combined with choledochoscopy in the treatment of secondary …