ERK signaling requires RAS-induced RAF dimerization and is limited by feedback. Activated
BRAF mutants evade feedback inhibition of RAS by either of two mechanisms. BRAF V600 …

Histiocytic neoplasms are clonal, hematopoietic disorders characterized by an accumulation
of abnormal, monocyte-derived dendritic cells or macrophages in Langerhans cell …

Lung cancer is one of the most devastating diseases worldwide with high incidence and
mortality. Hippo (Hpo) pathway is a conserved regulator of organ size in both Drosophila and …

High glycolysis, well known as "Warburg effect," is frequently observed in a variety of cancers.
Whether the deregulation of miRNAs contributes to the Warburg effect remains largely …

Antigen recognition by the T-cell receptor (TCR) is a hallmark of the adaptive immune
system. When the TCR engages a peptide bound to the restricting major histocompatibility …

LKB1 loss-of-function mutations, observed in ∼30% of human lung adenocarcinomas,
contribute significantly to lung cancer malignancy progression. We show that lysyl oxidase (LOX), …

Activating BRAF mutants and fusions signal as RAS-independent constitutively active dimers
with the exception of BRAF V600 mutant alleles which can function as active monomers 1 . …

Lineage transition in adenocarcinoma (ADC) and squamous cell carcinoma (SCC) of non-small
cell lung cancer, as implicated by clinical observation of mixed ADC and SCC …

Over 300 BRAF missense mutations have been identified in patients, yet currently approved
drugs target V600 mutants alone. Moreover, acquired resistance inevitably emerges, …

LKB1 regulates both cell growth and energy metabolism. It remains unclear how LKB1
inactivation coordinates tumor progression with metabolic adaptation in non-small cell lung …