Some cases of hereditary nonpolyposis colorectal cancer (HNPCC) are due to alterations in
a mutS-related mismatch repair gene. A search of a large database of expressed sequence …

TRAIL, also called Apo2L, is a cytotoxic protein that induces apoptosis of many transformed
cell lines but not of normal tissues, even though its death domain–containing receptor, DR4, …

During progression of atherosclerosis, myeloid cells destabilize lipid-rich plaques in the
arterial wall and cause their rupture, thus triggering myocardial infarction and stroke. Survivors …

How to obtain informative representations of molecules is a crucial prerequisite in AI-driven
drug design and discovery. Recent researches abstract molecules as graphs and employ …

MiRNAs are regulatory molecules that can be packaged into exosomes and secreted from
cells. Here, we show that adipose tissue macrophages (ATMs) in obese mice secrete miRNA-…

Exosomes are nanoparticles secreted by all cell types and are a large component of the
broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted, exosomes …

Context Systemic hypertension is prevalent among patients with obstructive sleep apnea (OSA).
Short-term studies indicate that continuous positive airway pressure (CPAP) therapy …

Integrin function is central to inflammation, immunity, and tumor progression. The urokinase-type
plasminogen activator receptor (uPAR) and integrins formed stable complexes that both …

Nucleotide excision repair, which is defective in xeroderma pigmentosum (XP), involves
incision of a DNA strand on each side of a lesion. We isolated a human gene homologous to …

Urokinase receptors, expressed on surfaces of many cell types, focus to the pericellular space
plasminogen-dependent proteolysis important in matrix remodeling and cell movement. …