[HTML][HTML] Targeting of histone deacetylases to reactivate tumour suppressor genes and its therapeutic potential in a human cervical cancer xenograft model
D Feng, J Wu, Y Tian, H Zhou, Y Zhou, W Hu, W Zhao… - PLoS …, 2013 - journals.plos.org
Aberrant histone acetylation plays an essential role in the neoplastic process via the
epigenetic silencing of tumour suppressor genes (TSGs); therefore, the inhibition of histone …
epigenetic silencing of tumour suppressor genes (TSGs); therefore, the inhibition of histone …
Induction of core symptoms of autism spectrum disorder by in vivo CRISPR/Cas9-based gene editing in the brain of adolescent rhesus monkeys
…, J Wu, WC Wang, YZ Hu, YL Gu, LB Lv, Y Yin, XT Hu… - Science Bulletin, 2021 - Elsevier
Although CRISPR/Cas9-mediated gene editing is widely applied to mimic human disorders,
whether acute manipulation of disease-causing genes in the brain leads to behavioral …
whether acute manipulation of disease-causing genes in the brain leads to behavioral …
[HTML][HTML] Effects of human mobility restrictions on the spread of COVID-19 in Shenzhen, China: a modelling study using mobile phone data
Background Restricting human mobility is an effective strategy used to control disease spread.
However, whether mobility restriction is a proportional response to control the ongoing …
However, whether mobility restriction is a proportional response to control the ongoing …
[HTML][HTML] Boosting the down-shifting luminescence of rare-earth nanocrystals for biological imaging beyond 1500 nm
In vivo fluorescence imaging in the near-infrared region between 1500–1700 nm (NIR-IIb
window) affords high spatial resolution, deep-tissue penetration, and diminished auto-…
window) affords high spatial resolution, deep-tissue penetration, and diminished auto-…
[HTML][HTML] Scalable salt-templated synthesis of two-dimensional transition metal oxides
Two-dimensional atomic crystals, such as two-dimensional oxides, have attracted much
attention in energy storage because nearly all of the atoms can be exposed to the electrolyte …
attention in energy storage because nearly all of the atoms can be exposed to the electrolyte …
Identification of PRRT2 as the causative gene of paroxysmal kinesigenic dyskinesias
Paroxysmal kinesigenic dyskinesias is a paroxysmal movement disorder characterized by
recurrent, brief attacks of abnormal involuntary movements induced by sudden voluntary …
recurrent, brief attacks of abnormal involuntary movements induced by sudden voluntary …
Abnormal histone modification patterns in lupus CD4+ T cells.
N Hu, X Qiu, Y Luo, J Yuan, Y Li, W Lei… - The Journal of …, 2008 - jrheum.org
OBJECTIVE: To investigate alterations in histone modifications in patients with systemic
lupus erythematosus (SLE). METHODS: Global histone H3/H4 acetylation and H3K4/H3K9 …
lupus erythematosus (SLE). METHODS: Global histone H3/H4 acetylation and H3K4/H3K9 …
Effect of glucagon‐like peptide‐1 receptor agonists on body weight in adults with obesity without diabetes mellitus—a systematic review and meta‐analysis of …
J Iqbal, HX Wu, N Hu, YH Zhou, L Li, F Xiao… - Obesity …, 2022 - Wiley Online Library
Clinical trials have investigated the weight loss effect of glucagon‐like peptide‐1 receptor
agonists (GLP‐1 RA) in adults with obesity without diabetes mellitus, but results for weight loss …
agonists (GLP‐1 RA) in adults with obesity without diabetes mellitus, but results for weight loss …
[PDF][PDF] Ancestral origins and genetic history of Tibetan highlanders
The origin of Tibetans remains one of the most contentious puzzles in history, anthropology,
and genetics. Analyses of deeply sequenced (30×–60×) genomes of 38 Tibetan highlanders …
and genetics. Analyses of deeply sequenced (30×–60×) genomes of 38 Tibetan highlanders …
PP-LCNet: A lightweight CPU convolutional neural network
…, S Dong, B Lu, Y Zhou, X Lv, Q Liu, X Hu… - arXiv preprint arXiv …, 2021 - arxiv.org
We propose a lightweight CPU network based on the MKLDNN acceleration strategy, named
PP-LCNet, which improves the performance of lightweight models on multiple tasks. This …
PP-LCNet, which improves the performance of lightweight models on multiple tasks. This …