While many diseases of aging have been linked to the immunological system, immune metrics
capable of identifying the most at-risk individuals are lacking. From the blood immunome …

Our primary objective is to provide the clinical informatics community with an introductory
tutorial on calibration measurements and calibration models for predictive models using …

The sharing of genomic data holds great promise in advancing precision medicine and providing
personalized treatments and other types of interventions. However, these opportunities …

Chinese hamster ovary (CHO) cells dominate biotherapeutic protein production and are widely
used in mammalian cell line engineering research. To elucidate metabolic bottlenecks in …

Sphingosine 1-phosphate (S1P) signaling regulates lymphocyte egress from lymphoid organs
into systemic circulation. The sphingosine phosphate receptor 1 (S1P 1 ) agonist FTY-720 …

Introducing engineered nanoparticles (NPs) into a biofluid such as blood plasma leads to
the formation of a selective and reproducible protein corona at the particle–protein interface, …

In plants, the activation of immunity is often inversely correlated with growth. Mechanisms
that control plant growth in the context of pathogen challenge and immunity are unclear. …

Background: Medical concepts are inherently ambiguous and error-prone due to human
fallibility, which makes it hard for them to be fully used by classical machine learning methods (…

Chinese hamster ovary (CHO) cells are the primary host for manufacturing of therapeutic
proteins. However, productivity loss is a major problem and is associated with genome …

Background The COVID-19 pandemic continues to ravage and burden hospitals around the
world. The epidemic started in Wuhan, China, and was subsequently recognized by the …