Global warming due to greenhouse gases (GHGs), mainly CO2, has become a serious
concern globally. Accordingly, electrocatalytic CO2 conversion provides an environment-friendly …

Motivation: Drug combinations are a promising strategy for combating complex diseases by
improving the efficacy and reducing corresponding side effects. Currently, a widely studied …

The aim of this study was to examine the comprehensive neuroprotective mechanism of
ligustrazine, which is extracted from Ligusticum Chuanxiong Hort., against vascular dementia (…

Single-atom catalysts (SACs) have been widely applied in electrocatalysis, photocatalysis
and advanced oxidation processes. However, the synthesis of Fe SACs supported by layered …

Ethnopharmacological relevance Vitiligo is a depigmentation disorder, which results in
substantial cosmetic disfigurement and poses a detriment to patients' physical as well as mental. …

A system-level identification of drug-target direct interactions is vital to drug repositioning
and discovery. However, the biological means on a large scale remains challenging and …

Cardiovascular diseases (CVDs) have been regarding as “the world’s first killer” of human
beings in recent years owing to the striking morbidity and mortality, the involved molecular …

Proteome profiling is a powerful tool in biological and biomedical studies, starting with samples
at bulk, single-cell, or single-cell-type levels. Reliable methods for extracting specific cell-…

Ubiquitination is a post-translational modification initiated by the E1 enzyme UBA1, which
transfers ubiquitin to ~35 E2 ubiquitin-conjugating enzymes. While UBA1 loss is cell lethal, it …

Background/aims Rehmanniae Radix (RR) and Cornus officinalis (CO) are a typical herbal
pair used to treat diabetic nephropathy (DN) in clinical practice. DN can be effectively treated …