The combination of Cas9, guide RNA and repair template DNA can induce precise gene
editing and the correction of genetic diseases in adult mammals. However, clinical …

RNA-based therapeutics have shown great promise in treating a broad spectrum of diseases
through various mechanisms including knockdown of pathological genes, expression of …

Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …

Messenger RNA (mRNA) therapeutics have been explored to treat various genetic disorders.
Lipid-derived nanomaterials are currently one of the most promising biomaterials that …

Dysfunctional endothelium contributes to more diseases than any other tissue in the body.
Small interfering RNAs (siRNAs) can help in the study and treatment of endothelial cells in …

Sepsis, a condition caused by severe infections, affects more than 30 million people
worldwide every year and remains the leading cause of death in hospitals 1 , 2 . Moreover, …

siRNA therapeutics have promise for the treatment of a wide range of genetic disorders.
Motivated by lipoproteins, we report lipopeptide nanoparticles as potent and selective siRNA …

Paclitaxel is widely used in cancer treatments, but poor water-solubility and toxicity raise
serious concerns. Here we report an RNA four-way junction nanoparticle with ultra-…

Emerging therapeutics that utilize RNA interference (RNAi) have the potential to treat broad
classes of diseases due to their ability to reversibly silence target genes. In August 2018, the …

A glucose-responsive closed-loop insulin delivery system represents the ideal treatment of
type 1 diabetes mellitus. In this study, we develop uniform injectable microgels for controlled …