BACKGROUND & AIMS: The limited clinical response observed in many patients with colorectal
cancer may be related to the presence of chemoresistant colorectal cancer stem cells (…

Similar to healthy tissues, many blood and solid malignancies are now thought to be organised
hierarchically, with a subset of stem-like cancer cells that self-renew while giving rise to …

Colon tumors may be maintained by a rare fraction of cancer stem-like cells (CSC) that express
the cell surface marker CD133. Self-renewing CSCs exhibit relatively greater resistance …

Endocrine therapies target the activation of the oestrogen receptor alpha (ERα) via distinct
mechanisms, but it is not clear whether breast cancer cells can adapt to treatment using drug-…

TGF-β/Activin induces epithelial-to-mesenchymal transition and stemness in pancreatic
ductal adenocarcinoma (PDAC). However, the microRNAs (miRNAs) regulated during this …

Resistant tumours are thought to arise from the action of Darwinian selection on genetically
heterogenous cancer cell populations. However, simple clonal selection is inadequate to …

Cancer stem cells (CSCs) resemble normal stem cells in several ways. Both cell types are
self‐renewing and when they divide, one of the daughter cells differentiates while the other …

Introduction Resistance to anti-estrogen therapies is a major cause of disease relapse and
mortality in estrogen receptor alpha (ERα)-positive breast cancers. Tamoxifen or estrogen …

Nicastrin (NCT) is a crucial component of the γ-secretase (GS) enzyme, which prompted
investigations into its biological role in cancer. We have previously shown that nicastrin is …

Over 30% of ERα breast cancer patients develop relapses and progress to metastatic disease
despite treatment with endocrine therapies. The pioneer factor PBX1 translates epigenetic …