User profiles for YoSon Park
 | YoSon ParkPerelman School of Medicine University of Pennsylvania Verified email at pennmedicine.upenn.edu Cited by 10648 |
[PDF][PDF] A quantitative proteome map of the human body
Determining protein levels in each tissue and how they compare with RNA levels is important
for understanding human biology and disease as well as regulatory processes that control …
for understanding human biology and disease as well as regulatory processes that control …
[PDF][PDF] Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease
Long non-coding RNA (lncRNA) genes have well-established and important impacts on
molecular and cellular functions. However, among the thousands of lncRNA genes, it is still a …
molecular and cellular functions. However, among the thousands of lncRNA genes, it is still a …
Transposable elements are the primary source of novelty in primate gene regulation
M Trizzino, YS Park, M Holsbach-Beltrame… - Genome …, 2017 - genome.cshlp.org
Gene regulation shapes the evolution of phenotypic diversity. We investigated the evolution
of liver promoters and enhancers in six primate species using ChIP-seq (H3K27ac and …
of liver promoters and enhancers in six primate species using ChIP-seq (H3K27ac and …
[HTML][HTML] Exploiting the GTEx resources to decipher the mechanisms at GWAS loci
The resources generated by the GTEx consortium offer unprecedented opportunities to
advance our understanding of the biology of human diseases. Here, we present an in-depth …
advance our understanding of the biology of human diseases. Here, we present an in-depth …
Renal compartment–specific genetic variation analyses identify new pathways in chronic kidney disease
Chronic kidney disease (CKD), a condition in which the kidneys are unable to clear waste
products, affects 700 million people globally. Genome-wide association studies (GWASs) …
products, affects 700 million people globally. Genome-wide association studies (GWASs) …
Pathogenesis, symptomatology, and transmission of SARS-CoV-2 through analysis of viral genomics and structure
The novel coronavirus SARS-CoV-2, which emerged in late 2019, has since spread around
the world and infected hundreds of millions of people with coronavirus disease 2019 (COVID…
the world and infected hundreds of millions of people with coronavirus disease 2019 (COVID…
Co-expression networks reveal the tissue-specific regulation of transcription and splicing
Gene co-expression networks capture biologically important patterns in gene expression
data, enabling functional analyses of genes, discovery of biomarkers, and interpretation of …
data, enabling functional analyses of genes, discovery of biomarkers, and interpretation of …
[PDF][PDF] Large, diverse population cohorts of hiPSCs and derived hepatocyte-like cells reveal functional genetic variation at blood lipid-associated loci
Genome-wide association studies have struggled to identify functional genes and variants
underlying complex phenotypes. We recruited a multi-ethnic cohort of healthy volunteers (n = …
underlying complex phenotypes. We recruited a multi-ethnic cohort of healthy volunteers (n = …
Identification and Development of Therapeutics for COVID-19
…, AN Skelly, B Ramsundar, J Wang, RR Goel, YS Park… - Msystems, 2021 - Am Soc Microbiol
After emerging in China in late 2019, the novel coronavirus severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) spread worldwide, and as of mid-2021, it remains a …
syndrome coronavirus 2 (SARS-CoV-2) spread worldwide, and as of mid-2021, it remains a …
Transcriptomic signatures across human tissues identify functional rare genetic variation
INTRODUCTION The human genome contains tens of thousands of rare (minor allele frequency
<1%) variants, some of which contribute to disease risk. Using 838 samples with whole-…
<1%) variants, some of which contribute to disease risk. Using 838 samples with whole-…