Highwire is an extremely large, evolutionarily conserved E3 ubiquitin ligase that negatively
regulates synaptic growth at the Drosophila NMJ. Highwire has been proposed to restrain …

Epidermal growth factor receptor pathway substrate clone 15 (Eps15) is a protein implicated
in endocytosis, endosomal protein sorting, and cytoskeletal organization. Its role is, however…

To identify novel proteins required for receptor-mediated endocytosis, we have developed
an RNAi-based screening method in Drosophila S2 cells, based on uptake of a scavenger …

Highwire is a huge, evolutionarily conserved protein that is required to restrain synaptic
growth and promote synaptic transmission at the Drosophila neuromuscular junction. Current …

Endosomal maturation is critical for accurate and efficient cargo transport through
endosomal compartments. Here we identify a mutation of the novel Drosophila gene, ema (endosomal …

Efficient synaptic transmission requires the apposition of neurotransmitter release sites
opposite clusters of postsynaptic neurotransmitter receptors. Transmitter is released at active …

Emerging evidence suggests that DNA repair deficiency and genome instability may be the
impending signs of many neurological diseases. Genome-wide association (GWAS) studies …

The congenital muscular dystrophies present in infancy with muscle weakness and are
often associated with mental retardation. Many of these inherited disorders share a common …

Synaptic growth is essential for the development and plasticity of neural circuits. To identify
molecular mechanisms regulating synaptic growth, we performed a gain-of-function screen …

Mutations in the tuberous sclerosis complex (TSC) are associated with various forms of
neurodevelopmental disorders, including autism and epilepsy. The heterodimeric TSC complex, …